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JNJ-1661010

CAT: 0804-HY-N7062-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N7062-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
JNJ-1661010 (Takeda-25) a potent and selective fatty acid amide hydrolase (FAAH) inhibitor with IC50s of 34 and 33 nM for rat FAAH and human FAAH, respectively. JNJ-1661010 can cross the blood-brain barrier and used as broad-spectrum analgesics[1][2].
CAS Number
681136-29-8
Product Name Alternative
Takeda-25
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
FAAH
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/jnj-1661010.html
Purity
99.77
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(NC1=CC=CC=C1)N(CC2)CCN2C3=NC(C4=CC=CC=C4)=NS3
Molecular Formula
C19H19N5OS
Molecular Weight
365.45
Precautions
H302, H315, H319, H335
References & Citations
[1]Keith JM, et al. Thiadiazolopiperazinyl ureas as inhibitors of fatty acid amide hydrolase. Bioorg Med Chem Lett. 2008 Sep 1;18 (17) :4838-43.|[2]Karbarz MJ, et al. Biochemical and biological properties of 4- (3-phenyl-[1,2,4] thiadiazol-5-yl) -piperazine-1-carboxylicacid phenylamide, a mechanism-based inhibitor of fatty acid amide hydrolase. Anesth Analg. 2009 Jan;108 (1) :316-29.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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CatalogName
A4361-25JNJ-1661010
sc-204023JNJ 1661010

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