SCH 32615

• Description :

  SCH 32615 is an enkephalinase (the enzymes responsible for the degradation of endogenous enkephalins) inhibitor. SCH 32615 can enhance surgery- and pregnancy-induced analgesia in mice[1][2].

• CAS Number :

  [83861-02-3]

• UNSPSC :

  12352005

• Target :

  Neprilysin

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/sch-32615.html

• Concentration :

  10mM

• Purity :

  99.68

• Solubility :

  DMSO : 125 mg/mL (ultrasonic)

• Smiles :

  OC([C@H](CC1=CC=CC=C1)N[C@H](C(NCCC(O)=O)=O)CC2=CC=CC=C2)=O

• Molecular Formula :

  C21H24N2O5

• Molecular Weight :

  384.43

• References & Citations :

  [1]Jayaram A, et, al. An enkephalinase inhibitor, SCH 32615, augments analgesia induced by surgery in mice. Anesthesiology. 1995 May;82 (5) :1283-7.|[2]Jayaram A, et, al. SCH 32615, an enkephalinase inhibitor, enhances pregnancy-induced analgesia in mice. Anesth Analg. 1995 May;80 (5) :944-8.|[3]Chipkin RE, et, al. Pharmacology of SCH 34826, an orally active enkephalinase inhibitor analgesic. J Pharmacol Exp Ther. 1988 Jun;245 (3) :829-38.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 2