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Elabela (19-32) (TFA)

CAT: 0804-HY-P2106A-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-P2106A-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Elabela (19-32) TFA is an active fragment of ELABELA (ELA) that binds to apelin receptor (APJ) . Elabela (19-32) TFA activates the Gαi1 and β-arrestin-2 signaling pathways with EC50s of 8.6 nM and 166 nM. Elabela (19-32) TFA induces receptor internalization and reduces arterial pressure, exerts positive inotropic effects on the heart[1].
UNSPSC
12352209
Target
Apelin Receptor (APJ) ; Arrestin
Type
Peptides
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/elabela-19-32-tfa.html
Purity
98.78
Solubility
DMSO : 100 mg/mL (ultrasonic) |H2O : 33.33 mg/mL (ultrasonic)
Smiles
OC(C(F)(F)F)=O.O=C(O)[C@H]1N(C([C@H](CC2=CC=CC=C2)NC([C@H]3N(C([C@H](C(C)C)NC([C@H](CCCNC(N)=N)NC([C@H](CO)NC([C@H](CC4=CNC=N4)NC([C@H](CC(C)C)NC([C@H]5N(C([C@H](CCSC)NC([C@H](CS)NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CC6)NC6=O)=O)=O)=O)=O)=O)CCC5)=O)=O)=O)=O)=O)=O)CCC3)=O)=O)CCC1
Molecular Formula
C77H120F3N25O19S2
Molecular Weight
1821.05
References & Citations
[1]Alexandre Murza, et al. Discovery and Structure-Activity Relationship of a Bioactive Fragment of ELABELA That Modulates Vascular and Cardiac Functions. J Med Chem. 2016 Apr 14;59 (7) :2962-72.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light, under nitrogen)
Scientific Category
Peptides
Clinical Information
No Development Reported
Citation 01
Free Radic Biol Med. 2022 Mar:181:130-142.|Nat Commun. 2025 Jul 21;16 (1) :6682.|Cell Stress Chaperones. 2023 Jan;28 (1) :91-103.|J Cardiovasc Transl Res. 2022 Jun;15 (3) :535-547.|Mol Med. 2024 Nov 20;30 (1) :223.

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