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Dabuzalgron

CAT: 0804-HY-117071-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-117071-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Dabuzalgron (Ro 115-1240) is an orally active and selective α-1A adrenergic receptor agonist for the treatment of urinary incontinence. Dabuzalgron protects against Doxorubicin-induced cardiotoxicity by preserving mitochondrial function[1].
CAS Number
219311-44-1
Product Name Alternative
Ro 115-1240
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Adrenergic Receptor; Apoptosis
Type
Reference compound
Related Pathways
Apoptosis; GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Endocrinology; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/dabuzalgron.html
Purity
98.72
Solubility
DMSO : 26 mg/mL (ultrasonic)
Smiles
CS(=O)(NC1=C(Cl)C=CC(OCC2=NCCN2)=C1C)=O
Molecular Formula
C12H16ClN3O3S
Molecular Weight
317.79
Precautions
H302, H315, H319, H335
References & Citations
[1]Beak J, et al. An Oral Selective Alpha-1A Adrenergic Receptor Agonist Prevents Doxorubicin Cardiotoxicity. JACC Basic Transl Sci. 2017 Feb;2 (1) :39-53.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
α adrenergic receptor

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