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LRWD1 rabbit pAb

CAT: 0855-ES15093-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES15093-01Size:50 µL
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Background
The protein encoded by this gene interacts with components of the origin recognition complex (ORC) and regulates the formation of the prereplicative complex. The encoded protein stabilizes the ORC and therefore aids in DNA replication. This protein is required for the G1/S phase transition of the cell cycle. In addition, the encoded protein binds to trimethylated histone H3 in heterochromatin and recruits the ORC and lysine methyltransferases, which help maintain the repressive heterochromatic state. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]
Description
The protein encoded by this gene interacts with components of the origin recognition complex (ORC) and regulates the formation of the prereplicative complex. The encoded protein stabilizes the ORC and therefore aids in DNA replication. This protein is required for the G1/S phase transition of the cell cycle. In addition, the encoded protein binds to trimethylated histone H3 in heterochromatin and recruits the ORC and lysine methyltransferases, which help maintain the repressive heterochromatic state. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015],
UniProt
Q9UFC0
Swiss Prot
Q9UFC0
Reactivity
Human; Mouse
Immunogen
Synthesized peptide derived from human LRWD1 AA range: 395-445
Target
LRWD1
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC
Concentration
1 mg/ml
Dilution
WB 1:500-2000; IHC-p 1:50-300
Buffer
-20°C/1 year
Storage Conditions
-20°C/1 year
Fragment
IgG
Subcellular Location
Nucleus . Chromosome, centromere. Chromosome, telomere. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Chromosome, centromere, kinetochore . Localizes to heterochromatin during G1 phase. Restricted to centromeres or telomeres as cells progress though S phase. When cells enter mitosis, relocalizes to centromeres. Recruitment to pericentric heterochromatin largely depends on the presence of H3K9me3.
Gene ID (Human)
222229

UniProtKB · Q9UFC0

Leucine-rich repeat and WD repeat-containing protein 1

LRWD1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q9UFC0
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
LRWD1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
A8K4K2, B2R9G2, Q8N0T9, Q8WV43, Q96GJ2
Protein keywords

Cellular component

CentromereChromosomeCytoplasmCytoskeletonKinetochoreNucleusTelomere

Molecular function

Chromatin regulator

Biological process

DNA replication

Domain

Leucine-rich repeatRepeatWD repeat

PTM

PhosphoproteinUbl conjugation

Technical term

Proteomics identificationReference proteome

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