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ICA-105574

CAT: 0804-HY-124702-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-124702-01Size:5 mg
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Description
ICA-105574 is a potent and efficacious hERG channel activator. The primary mechanism by which ICA-105574 potentiates hERG channel activity is by removing hERG channel inactivation. ICA-105574 steeply potentiates current amplitudes more than 10-fold with an EC50 value of 0.5 +/- 0.1 μM and a Hill slope (n (H) ) of 3.3 +/- 0.2. ICA-105574 can prevent arrhythmias induced by cardiac delayed repolarization. ICA-105574 shortens action potential duration in ventricular myocytes concentration-dependently[1][2].
CAS Number
316146-57-3
UNSPSC
12352005
Hazard Statement
H317, H319, H400
Target
Potassium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/ica-105574.html
Purity
99.25
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
O=C(NC1=CC=C(OC2=CC=CC=C2)C=C1)C3=CC=CC([N+]([O-])=O)=C3
Molecular Formula
C19H14N2O4
Molecular Weight
334.33
Precautions
H317, H319, H400
References & Citations
[1]Gerlach AC, et al. Pharmacological removal of human ether-à-go-go-related gene potassium channel inactivation by 3-nitro-N- (4-phenoxyphenyl) benzamide (ICA-105574) . Mol Pharmacol. 2010;77 (1) :58-68.|[2]Meng, J., et al., (2013) . Compound ICA-105574 prevents arrhythmias induced by cardiac delayed repolarization. European journal of pharmacology, 718 (1-3), 87–97.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

Ica-105574
CAS Number316146-57-3
PubChem CID715924
IUPAC Name3-nitro-N-(4-phenoxyphenyl)benzamide
Molecular FormulaC19H14N2O4
Molecular Weight334.3
XLogP4.1
Topological Polar Surface Area84.2
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count4
Heavy Atom Count25
Formal Charge0
Complexity451
SMILES
C1=CC=C(C=C1)OC2=CC=C(C=C2)NC(=O)C3=CC(=CC=C3)[N+](=O)[O-]
InChI
InChI=1S/C19H14N2O4/c22-19(14-5-4-6-16(13-14)21(23)24)20-15-9-11-18(12-10-15)25-17-7-2-1-3-8-17/h1-13H,(H,20,22)
InChIKey
GDWKBKTVROCPNZ-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Ica-105574
CAS: 316146-57-3
CID: 715924
Formula: C19H14N2O4
MW: 334.3
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight334.3
XLogP34.1
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count4
Exact Mass334.09535693
Monoisotopic Mass334.09535693
Topological Polar Surface Area84.2 Ų
Heavy Atom Count25
Formal Charge0
Complexity451
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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