Products for Research Use Only
RegisterLogin

ICA-105574

CAT: 0804-HY-124702-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-124702-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
ICA-105574 is a potent and efficacious hERG channel activator. The primary mechanism by which ICA-105574 potentiates hERG channel activity is by removing hERG channel inactivation. ICA-105574 steeply potentiates current amplitudes more than 10-fold with an EC50 value of 0.5 +/- 0.1 μM and a Hill slope (n (H) ) of 3.3 +/- 0.2. ICA-105574 can prevent arrhythmias induced by cardiac delayed repolarization. ICA-105574 shortens action potential duration in ventricular myocytes concentration-dependently[1][2].
CAS Number
316146-57-3
UNSPSC
12352005
Hazard Statement
H317, H319, H400
Target
Potassium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/ica-105574.html
Purity
99.25
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
O=C(NC1=CC=C(OC2=CC=CC=C2)C=C1)C3=CC=CC([N+]([O-])=O)=C3
Molecular Formula
C19H14N2O4
Molecular Weight
334.33
Precautions
H317, H319, H400
References & Citations
[1]Gerlach AC, et al. Pharmacological removal of human ether-à-go-go-related gene potassium channel inactivation by 3-nitro-N- (4-phenoxyphenyl) benzamide (ICA-105574) . Mol Pharmacol. 2010;77 (1) :58-68.|[2]Meng, J., et al., (2013) . Compound ICA-105574 prevents arrhythmias induced by cardiac delayed repolarization. European journal of pharmacology, 718 (1-3), 87–97.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-22044-01ICA
HY-150333-01MMB-ICA
HY-101396-01ICA-069673
HY-108587-01ICA 110381
HY-122114-01ICA-27243
HY-16787-01ICA-121431
HY-175124ADB-ICA
HY-175099AB-ICA
HY-125469-01ICA-105665
HY-101396RICA-069673 (Standard)

Alternative Products

CatalogName
MBS133283ICA-105574
MBS5754977ICA
YP-W19480-01Human ICA (ICA) ELISA Kit

Popular Products