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ICA-069673

CAT: 0804-HY-101396-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-101396-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ICA-069673 is a KCNQ2/Q3 potassium channel activator. ICA-069673 demonstrates greater selectivity for KV7.2/7.3 over KV7.3/KV7.5, with EC50s of 0.69 μM and 14.3 μM, respectively. ICA-069673 inhibits spontaneous phasic and nerve-evoked contractions in guinea pig detrusor smooth muscle (DSM) . ICA-069673 also decreases the global intracellular Ca (2+) concentration in DSM cells[1][2].
CAS Number
582323-16-8
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Potassium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ICA-069673.html
Purity
99.20
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(NC1=CN=C(Cl)N=C1)C2=CC=C(F)C(F)=C2
Molecular Formula
C11H6ClF2N3O
Molecular Weight
269.63
Precautions
H302, H315, H319, H335
References & Citations
[1]Provence A, et al. The Novel KV7.2/KV7.3 Channel Opener ICA-069673 Reveals Subtype-Specific Functional Roles in Guinea Pig Detrusor Smooth Muscle Excitability and Contractility. J Pharmacol Exp Ther. 2015 Sep;354 (3) :290-301.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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B7640-100ICA 069673
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A20576-25ICA-069673 25mg
A20576-5ICA-069673 5mg
A20576-50ICA-069673 50mg
A20576-10ICA-069673 10mg
A20576-100ICA-069673 100mg
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