ICA-105665

CAT: 0804-HY-125469-01Size: 5 mgDry Ice: NoHazardous: No

1 / 1

CAT#:0804-HY-125469-01Size:5 mg

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

Quick Request Actions

Description

ICA-105665 (PF-04895162) is a potent and orally active neuronal Kv7.2/7.3 and Kv7.3/7.5 potassium channels opener. ICA-105665 inhibits liver mitochondrial function and bile salt export protein (BSEP) transport (IC50 of 311 μM) . ICA-105665 can penetrate the blood-brain barrier and has antiseizure effects[1][2][3][4].

CAS Number

2694728-63-5

Product Name Alternative

PF-04895162

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Potassium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/ica-105665.html

Concentration

10mM

Purity

99.85

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

O=C(NN1C(C2CC2)=NC3=C(C=CC(F)=C3)C1=O)CC4=CC=C(F)C=C4

Molecular Formula

C19H15F2N3O2

Molecular Weight

355.34

Precautions

H302, H315, H319, H335

References & Citations

[1] Aleo MD, et al. Phase I study of PF‐04895162, a Kv7 channel opener, reveals unexpected hepatotoxicity in healthy subjects, but not rats or monkeys: clinical evidence of disrupted bile acid homeostasis. Pharmacol Res Perspect. 2019 Feb;7 (1) :e00467.|[2]Generaux G, et al. Quantitative systems toxicology (QST) reproduces species differences in PF-04895162 liver safety due to combined mitochondrial and bile acid toxicity. Pharmacol Res Perspect. 2019 Oct 9;7 (6) :e00523.|[3]Kasteleijn-Nolst Trenité DG, et al. Kv7 potassium channel activation with ICA-105665 reduces photoparoxysmal EEG responses in patients with epilepsy. Epilepsia. 2013 Aug;54 (8) :1437-43.|[4]Bialer M, et al. Progress report on new antiepileptic drugs: a summary of the Eleventh Eilat Conference (EILAT XI) . Epilepsy Res. 2013 Jan;103 (1) :2-30.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

Phase 2

Related Products

Catalog	Name
HY-22044-01	ICA
HY-150333-01	MMB-ICA
HY-101396-01	ICA-069673
HY-108587-01	ICA 110381
HY-16787-01	ICA-121431
HY-122114-01	ICA-27243
HY-175124	ADB-ICA
HY-124702-01	ICA-105574
HY-175099	AB-ICA
HY-101396R	ICA-069673 (Standard)

Alternative Products

Catalog	Name
BA6882-25	ICA-105665
MBS5754977	ICA
YP-W19480-01	Human ICA (ICA) ELISA Kit
B5802-5	ICA 121431
B7640-5	ICA 069673
255482-01	ICA 110381
M20736-01	ICA-121431

ICA-105665

Related Products

Alternative Products

Popular Products