ICA

• Description :

  ICA (N- (pyridin-2-yl) -4- (pyridin-2-yl) thiazol-2-amine) is a SK channel inhibitor that has antileishmanial activity with an IC50 of 2.1 μM.

• Product Name Alternative :

  N-[4- (2-Pyridinyl) -2-thiazolyl]-2-pyridinamine

• UNSPSC :

  12352005

• Target :

  Parasite

• Type :

  Reference compound

• Related Pathways :

  Anti-infection

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Infection; Cardiovascular Disease

• Assay Protocol :

  https://www.medchemexpress.com/ICA.html

• Purity :

  99.92

• Solubility :

  DMSO : ≥ 49.5 mg/mL

• Smiles :

  C1(NC2=NC(C3=NC=CC=C3)=CS2)=NC=CC=C1

• Molecular Formula :

  C13H10N4S

• Molecular Weight :

  254.31

• References & Citations :

  [1]Bhuniya D, et al. Aminothiazoles: Hit to lead development to identify antileishmanial agents. Eur J Med Chem. 2015 Sep 18;102:582-93.|[2]Skibsbye L, et al. Antiarrhythmic Mechanisms of SK Channel Inhibition in the Rat Atrium. J Cardiovasc Pharmacol. 2015 Aug;66 (2) :165-76.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  Leishmania

• CAS Number :

  [3374-88-7]