5-Ethynyluridine

5-Ethynyluridine

• CAS Number: 69075-42-9
• UNSPSC Description: 5-Ethynyluridine (5-EU) is a potent cell-permeable nucleoside can be used to label newly synthesized RNA. 5-Ethynyluridine can be used for isolation and sequencing of nascent RNA from neuronal populations in vivo. 5-Ethynyluridine can be used to identify changes in transcription in vivo in nervous system disease models[1][2]. 5-Ethynyluridine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
• Target Antigen: Biochemical Assay Reagents
• Type: Reference compound
• Related Pathways: Others
• Field of Research: Others
• Assay Protocol: https://www.medchemexpress.com/5-ethynyluridine.html
• Solubility: DMSO : 100 mg/mL (ultrasonic)
• Smiles: OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C(NC(C(C#C)=C2)=O)=O)O1
• Molecular Weight: 268.22
• References & Citations: [1]Van't Sant LJ, et al. In vivo 5-ethynyluridine (EU) labelling detects reduced transcription in Purkinje cell degeneration mouse mutants, but can itself induce neurodegeneration. Acta Neuropathol Commun. 2021 May 21;9(1):94.|[2]Jao CY, et al. Exploring RNA transcription and turnover in vivo by using click chemistry. Proc Natl Acad Sci U S A. 2008 Oct 14;105(41):15779-84.
• Shipping Conditions: Room Temperature
• Clinical Information: No Development Reported