5-Ethynyluridine

CAT: 0804-HY-141140-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-141140-01Size:5 mg
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Description
5-Ethynyluridine (5-EU) is a potent cell-permeable nucleoside can be used to label newly synthesized RNA. 5-Ethynyluridine can be used for isolation and sequencing of nascent RNA from neuronal populations in vivo. 5-Ethynyluridine can be used to identify changes in transcription in vivo in nervous system disease models[1][2]. 5-Ethynyluridine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
CAS Number
[69075-42-9]
Product Name Alternative
5-EU
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Biochemical Assay Reagents
Type
Reference compound
Related Pathways
Others
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/5-ethynyluridine.html
Concentration
10mM
Purity
99.15
Solubility
DMSO : 100 mg/mL (ultrasonic) |H2O : 25 mg/mL (ultrasonic)
Smiles
OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C(NC(C(C#C)=C2)=O)=O)O1
Molecular Formula
C11H12N2O6
Molecular Weight
268.22
Precautions
H302, H315, H319, H335
References & Citations
[1]Van't Sant LJ, et al. In vivo 5-ethynyluridine (EU) labelling detects reduced transcription in Purkinje cell degeneration mouse mutants, but can itself induce neurodegeneration. Acta Neuropathol Commun. 2021 May 21;9 (1) :94.|[2]Jao CY, et al. Exploring RNA transcription and turnover in vivo by using click chemistry. Proc Natl Acad Sci U S A. 2008 Oct 14;105 (41) :15779-84.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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Alternative Products

CatalogName
MBS57851135-Ethynyluridine
296116-015-Ethynyluridine-5'-triphosphate sodium salt
436399-015-Ethynyluridine discontinued. See 296117
MBS58260682'-beta-C-Ethynyluridine
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MBS58260713'-beta-C-Ethynyluridine
sc-500350(2′S) -2′-Deoxy-2′-fluoro-5-ethynyluridine
TRC-D232980-100MG(2’S)-2’-Deoxy-2’-fluoro-5-ethynyluridine
3438-100mgF-ara-EdU (2′-Deoxy-2′-fluoro-5-ethynyluridine), 100 mg
3438-500mgF-ara-EdU (2′-Deoxy-2′-fluoro-5-ethynyluridine), 500 mg

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