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USP14 Recombinant Protein

CAT: 0223-91-171Size: 0.05 mgDry Ice: YesHazardous: No
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CAT#:0223-91-171Size:0.05 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Ubiquitin Carboxyl-Terminal Hydrolase 14 (USP14) belongs to the ubiquitin-specific processing (USP) family which is a deubiquitinating enzyme (DUB) with His and Cys domains. USP14 located in the cytoplasm is a proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated proteins. USP14 acts also as a physiological inhibitor of endoplasmic reticulum-associated degradation (ERAD) under the non-stressed condition by inhibiting the degradation of unfolded endoplasmic reticulum proteins via interaction with ERN1. In addition, USP14 is indispensable for synaptic development and function at neuromuscular junctions, required for the degradation of the chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis.
CAS Number
9000-83-3
NCBI Gene ID
9097
Swiss Prot
P54578
Accession Number
P54578
Tag
N-6 His tag
Type
Recombinant Proteins
Source
E. coli
Field of Research
Cell Cycle
Buffer
Supplied as a 0.2 um filtered solution of 20mM TrisHCl, 100mM NaCl, 20% Glycerol, pH 8.0. It is not recommended to reconstitute to a concentration less than 100 ug/ml.
Shipping Conditions
Dry Ice
Calculated Molecular Weight
48.45 kD
Applications Notes
This recombinant protein can be used for biological assays. For research use only.
NCBI Official Name
Ubiquitin specific peptidase 14
NCBI Organism
Homo sapiens
Other Product Names
Ubiquitin Carboxyl-Terminal Hydrolase 14, Deubiquitinating Enzyme 14, Ubiquitin Thioesterase 14, Ubiquitin-Specific-Processing Protease 14, USP14, TGT
Species
Human
Physical Properties
Liquid

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