USP14 Antibody

• Background :

  This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. This protein is located in the cytoplasm and cleaves the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins. Mice with a mutation that results in reduced expression of the ortholog of this protein are retarded for growth, develop severe tremors by 2 to 3 weeks of age followed by hindlimb paralysis and death by 6 to 10 weeks of age. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

• NCBI Gene ID :

  9097

• Swiss Prot :

  P54578

• Accession Number :

  P54578

• Host :

  Rabbit

• Reactivity :

  Human

• Immunogen :

  This USP14 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 355-383 amino acids from the C-terminal region of human USP14.

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Cell Cycle

• Purification :

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration :

  Batch dependent

• Homology :

  Predicted species reactivity based on immunogen sequence: Mouse, Bovine

• Buffer :

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight :

  56 kDa

• Fragment :

  Rabbit Ig

• Applications Notes :

  For WB starting dilution is: 1:1000

• Symbol :

  USP14

• NCBI Official Name :

  Ubiquitin carboxyl-terminal hydrolase 14

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  Davila, S., et al. Genes Immun. 11 (3) :232-238 (2010)

• Background Reference 02 :

  Chen, P.C., et al. J. Neurosci. 29 (35) :10909-10919 (2009)

• Background Reference 03 :

  Mines, M.A., et al. J. Biol. Chem. 284 (9) :5742-5752 (2009)

• Background Reference 04 :

  Nagai, A., et al. Biochem. Biophys. Res. Commun. 379 (4) :995-1000 (2009)

• Other Product Names :

  Ubiquitin carboxyl-terminal hydrolase 14, Deubiquitinating enzyme 14, Ubiquitin thioesterase 14, Ubiquitin-specific-processing protease 14, USP14, TGT

• Tested Applications :

  WB

• Protein ID :

  1729927

• Physical Properties :

  Liquid