TNF RII Recombinant Protein

• Background:

  Tumor necrosis factor receptor superfamily member 1B (TNFRSF1B) is a member of the tumor necrosis factor receptor superfamily. Human TNF RII contains four cysteinerich repeats in its ECD, which shares 58% and 56% amino acid sequence identity with the mouse and rat orthologs, respectively.TNF RII is expressed predominantly on cells of the hematopoietic lineage, such as T and natural killer cells, as well as on endothelial cells, microglia, astrocytes, neurons, oligodendrocytes, cardiac myocytes, thymocytes, and mesenchymal stem cells.TNF RII binds to the membranebound forms of TNF alpha and Lymphotoxin alpha/TNF beta ;soluble TNF is thought to signal predominately through TNF RI.Soluble TNF RII is believed to inhibit TNF biological activity by binding TNF thereby preventing it from activating membrane TNF receptors.

• NCBI Gene ID:

  7133

• Swiss Prot:

  P20333

• Accession Number:

  P20333

• Tag:

  C-Fc tag

• Type:

  Recombinant Proteins

• Source:

  Human Cells

• Field of Research:

  Apoptosis, Chemokines & Cytokines, Growth Factors, Immunology, Other

• Buffer:

  Lyophilized from a 0.2 um filtered solution of PBS, pH7.4. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in ddH4O.

• Shipping Conditions:

  Room Temp

• Calculated Molecular Weight:

  51.9 kD

• Applications Notes:

  This recombinant protein can be used for biological assays. For research use only.

• NCBI Official Name:

  Tumor necrosis factor receptor superfamily member 1B

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  Tumor necrosis factor receptor superfamily member 1B, TNFRSF1B, Tumor necrosis factor receptor 2, TNF-R2, TNF-RII, Tumor necrosis factor receptor type II, p75, p80 TNF-alpha receptor, CD120b

• Species:

  Human

• Physical Properties:

  Lyophilized

• CAS Number:

  9000-83-3