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DR5 Recombinant Protein

CAT: 0223-96-750Size: 0.1 mgDry Ice: NoHazardous: No
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CAT#:0223-96-750Size:0.1 mg
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Background
Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B) is also known as TNF-related apoptosis-inducing ligand receptor 2 (TRAILR2), Death receptor 5 (DR5), CD262, KILLER, is a member of the TNF-receptor superfamily, and contains an intracellular death domain. TNFRSF10B / DR-5 is widely expressed in adult and fetal tissues; very highly expressed in tumor cell lines. TRAILR2 / CD262 / DR5 is the receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD (a death domain containing adaptor protein) of TRAIL-R2 / TNFRSF10B recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. CD262 / DR5 Promotes the activation of NF-kappa-B. DR5 is essential for ER stress-induced apoptosis and is regulated by p53/TP53.
CAS Number
9000-83-3
NCBI Gene ID
8795
Swiss Prot
O14763
Accession Number
NP_003833
Tag
C-Fc Tag
Type
Recombinant Proteins
Source
HEK293 cells
Field of Research
Apoptosis, Cancer, Homeostasis, Immunology, Other
Purity
>95% as determined by SDS-PAGE.
Buffer
50 mM Tris, 100 mM NaCl, pH7.5
Shipping Conditions
Room Temp
Storage Conditions
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Calculated Molecular Weight
40.5 kDa
Applications Notes
This recombinant protein can be used for WB. For research use only.
NCBI Official Name
Tumor necrosis factor receptor superfamily, member 10b
NCBI Organism
Homo sapiens
Background Reference 01
Yamaguchi H., et al., 2004, J. Biol. Chem. 279:45495-45502.
Background Reference 02
Gajate Consuelo, et al., 2005, J. Biol. Chem. (United States) 280 (12) : 11641–7.
Background Reference 03
Chaudhary, P M., et al., 1997, Immunity (UNITED STATES) 7 (6) : 821–30.
Other Product Names
TNFRSF10B, TRAILR2, TRAIL-R2, CD262, DR5, KILLER, TRICK2, ZTNFR9, TRICKB
Tested Applications
WB
Species
Human
Physical Properties
Lyophilized

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