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DR5 Antibody

CAT: 0223-2019-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-2019-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
DR5 Antibody: Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. TRAIL/Apo2L is a new member of the TNF family. DR4 was recently identified as the receptor for TRAIL. A novel death domain containing receptor for TRAIL was more recently identified and designated DR5, Apo2, TRAIL-R2, TRICK2, or KILLER by several groups independently. Like DR4, DR5 transcript is widely expressed in normal tissues and in many types of tumor cells. DR5 binds to TRAIL and mediates TRAIL induced cell death. Overexpression of DR5 induces apoptosis and activates NF-κ B.
NCBI Gene ID
8795
Swiss Prot
O14763
Accession Number
AF012535
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Validation
KO Validation (Figure 12) shows DR5 expression detected by anti-DR5 antibodies (2019) was disrupted in DR5 KO HCT116 cells. KO Validation2019 KD validation (Figure 13) : Anti-DR5 antibody (2019) specificity was further verified by DR5 specific knockdown. DR5 signal in MB231 cells transfected with DR5 siRNAs was disrupted in comparison with that in cells transfected with control siRNAs. KD validation2019 Regulated expression validation (Figure 12, 15) : DR5 expression detected by anit-DR5 antibodies (2019) was up-regulated by carfilzomib treatment and was down-regulated by treatment with two or more cytokines. Regulated expression validation2019
Field of Research
Apoptosis
Purification
DR5 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1201 - HeLa Cell Lysate
Concentration
1 mg/ml
Buffer
DR5 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
DR5 antibody can be stored at 4˚ C up to one year. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Specificity
Antibody has no cross reaction to DR4.
Isoform
Human DR5 has 3 isoforms, including isoform L (440aa, 48kD), isoform S (411aa, 45kD) and isoform 3 (118aa, 13kD) . Mouse DR5 has 1 isoform (381aa, 42kD), and Rat DR5 also has 1 isoform (336aa, 37kD) . 2019 can detect two human isoforms and can also detect mouse and rat isoforms.
Symbol
TNFRSF10B
Positive Control 2
Cat. No. 1204 - K562 Cell Lysate
Positive Control 3
Cat. No. 17-001 - HeLa Cell Slide
Positive Control 4
Cat. No. 1282 - 3T3/NIH Cell Lysate
Positive Control 5
Cat. No. 1285 - C2C12 Cell Lysate
NCBI Official Name
Tumor necrosis factor receptor superfamily, member 10b
NCBI Organism
Homo sapiens
Background Reference 01
Pan et al. Science 1997;277:815-8.
Background Reference 02
Sheridan et al. Science 1997;277:818-21.
Background Reference 03
Walczak et al. EMBO J 1997;16:5386-97.
Background Reference 04
MacFarlane et al. J Biol Chem 1997;272:25417-20
Citation 01
26009898
Citation 02
18266105
Citation 03
27827395
Citation 04
11859410
Citation 05
19570774
Citation 06
17470478
Citation 07
21953056
Citation 08
20371690
Citation 09
21385927
Citation 10
23766363
Citation 11
23833311
Citation 12
23319802
Citation 13
21685476
Citation 14
18846110
Citation 15
20562908
Citation 16
18193086
Citation 17
18362888
Citation 18
27387452
Citation 19
30059709
Citation 20
24287696
Other Product Names
DR5 Antibody: DR5, CD262, KILLER, TRICK2, TRICKB, ZTNFR9, TRAILR2, TRICK2A, TRICK2B, TRAIL-R2, KILLER/DR5, DR5, UNQ160/PRO186, Tumor necrosis factor receptor superfamily member 10B, Death receptor 5, TRAIL receptor 2
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
2338419
Physical Properties
Liquid

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