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DR5 Antibody

CAT: 0223-99-188Size: 0.1 mgDry Ice: NoHazardous: No
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CAT#:0223-99-188Size:0.1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
DR5, also known as TRAIL-R2, TRICK2 and KILLER, is a widely expressed type I membrane member of the tumor necrosis (TNF) receptor family. Members of this family contain multiple cysteine-rich repeats in their extracellular domain and while the cytoplasmic region is less conserved, they do contain an intracellular 80 amino acid motif known as the ‘death domain’ (DD) . DR5 is a receptor for the cytotoxic ligand TRAIL which induces apoptosis and it is the cytoplasmic DD that is responsible for transducing the death process. DR5 has also been shown to activate NF-κB.
Host
Rabbit
Reactivity
Human
Immunogen
Recombinant DR5
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Signal Transduction, Immunology
Concentration
0.5 mg/mL
Buffer
Supplied in borate buffered saline, pH 8.2; No preservatives or amine-containing buffer salts added
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store vial at 2-8˚ C
Fragment
IgG
Specificity
DR5
Applications Notes
DR5 Antibody for use in flow cytometry, immunocytochemistry, and western blotting assays.
Tested Applications
IHC-Fr, ICC, Flow, Blocking, IP
Physical Properties
Liquid

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