TNF-alpha Recombinant Protein

• Background:

  TNF-a is a pleiotrophic pro-inflammatory cytokine secreted by various cells including adipocytes, activated monocytes, macrophages, B cells, T cells and fibroblasts. It belongs to the TNF family of ligands and signals through two receptors, TNFR1 and TNFR2. TNF-a is cytotoxic to a wide variety of tumor cells and is an essential factor in mediating the immune response against bacterial infections. TNF-a also plays a role in the induction of septic shock, auto immune diseases, rheumatoid arthritis, inflammation, and diabetes. Recombinant human TNF-a is a soluble 157 amino acid protein (17.4 kDa) which corresponds to C-terminal extracellular domain of the full length transmembrane protein.

• NCBI Gene ID:

  7124

• Swiss Prot:

  P01375

• Accession Number:

  NP_000585.2

• Type:

  Recombinant Proteins

• Source:

  E. coli

• Field of Research:

  Apoptosis, Cancer, Chemokines & Cytokines, Growth Factors, Immunology, Innate Immunity, Obesity, Signal Transduction

• Purity:

  Greater than 98% by SDS-PAGE gel and HPLC analyses.

• Shipping Conditions:

  Room Temp

• Storage Conditions:

  The lyophilized TNF-alpha recombinant protein is stable for at least 2 years from date of receipt at -20˚ C. Reconstituted TNF-alpha is stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚ C. As with any protein, exposing TNF-alpha recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.

• NCBI Official Name:

  Tumor necrosis factor

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  DIF, TNFA, TNFSF2, TNF-alpha, Tumor necrosis factor, Cachectin, TNF-a

• Species:

  Human

• Protein ID:

  25952111

• Physical Properties:

  Lyophilized

• CAS Number:

  9000-83-3