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TIMP-2 Recombinant Protein

CAT: 0223-96-957Size: 0.05 mgDry Ice: NoHazardous: No
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CAT#:0223-96-957Size:0.05 mg
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Background
TIMP metallopeptidase inhibitor 2 is also known as TIMP2, which belongs to the protease inhibitor I35 (TIMP) family. This family protein are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. The TIMP family encompasses four members (TIMP1, TIMP2, TIMP3, TIMP4), and they inhibit most MMPs by forming non-covalent binary complex. In addition to an inhibitory role against metalloproteinases, TIMP2 has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, TIMP-2 may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix.
CAS Number
9000-83-3
NCBI Gene ID
7077
Swiss Prot
P16035
Accession Number
NP_003246.1
Tag
His Tag
Type
Recombinant Proteins
Source
HEK293 cells
Field of Research
Other
Buffer
50 mM Tris, 150 mM NaCl, pH7.5
Shipping Conditions
Room Temp
Storage Conditions
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Calculated Molecular Weight
22.6 kDa
Applications Notes
This recombinant protein can be used for WB. For research use only.
NCBI Official Name
Metalloproteinase inhibitor 2 precursor
NCBI Organism
Homo sapiens
Background Reference 01
Stetler-Stevenson W.G., et al., 1989, J. Biol. Chem. 264:17374-17378.
Background Reference 02
Goldberg G.I., et al., 1989, Proc. Natl. Acad. Sci. U.S.A. 86:8207-8211.
Background Reference 03
Chattopadhyay N., et al., 2001, J. Cancer Res. Clin. Oncol. 127:653-658.
Other Product Names
CSC-21K, TIMP2
Tested Applications
WB
Species
Human
Physical Properties
Lyophilized

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