PSCA Recombinant Protein

CAT: 0223-11-372Size: 0.1 mgDry Ice: NoHazardous: No
CAT#:0223-11-372Size:0.1 mg
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Background
The Prostate stem cell antigen (PSCA) is a glycosylphosphatidylinositol (GPI) -anchored protein, plays an important role in tumorigenesis. The prostate stem cell antigen (PSCA) gene, which encodes a prostate-specific antigen (PSA), was identified as a gene involved in cell adhesion and proliferation. PSCA may be involved in the regulation of cell proliferation. Has a cell-proliferation inhibition activity in vitro. May act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro inhibits nicotine-induced signaling probably implicating alpha-3:beta-2- or alpha-7-containing nAChRs.
CAS Number
9000-83-3
NCBI Gene ID
8000
Swiss Prot
O43653
Accession Number
NP_005663.2
Tag
His Tag
Type
Recombinant Proteins
Source
HEK293 cells
Purity
>90% as determined by SDS-PAGE.
Buffer
PBS, pH7.4
Shipping Conditions
Room Temp
Storage Conditions
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Calculated Molecular Weight
10.4 kDa
Applications Notes
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 10.4 kDa. The protein migrates as 18-25 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
NCBI Official Name
Prostate stem cell antigen
NCBI Organism
Homo sapiens
Background Reference 01
Sakamoto H, et al. 2008. Nat Genet. 40 (6) :730-40.
Background Reference 02
Jensen MM, et al. 2015. Neurobiol Aging. 36 (4) :1629-1638.
Background Reference 03
Li E, et al. 2017. Prostate. 77 (16) :1563-1572.
Other Product Names
PSCA, UNQ206, PRO232
Tested Applications
WB
Species
Human
Physical Properties
Lyophilized

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