PSCA Recombinant Protein

• Background:

  The Prostate stem cell antigen (PSCA) is a glycosylphosphatidylinositol (GPI) -anchored protein, plays an important role in tumorigenesis. The prostate stem cell antigen (PSCA) gene, which encodes a prostate-specific antigen (PSA), was identified as a gene involved in cell adhesion and proliferation. PSCA may be involved in the regulation of cell proliferation. Has a cell-proliferation inhibition activity in vitro. May act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro inhibits nicotine-induced signaling probably implicating alpha-3:beta-2- or alpha-7-containing nAChRs.

• NCBI Gene ID:

  8000

• Swiss Prot:

  O43653

• Accession Number:

  NP_005663.2

• Tag:

  His Tag

• Type:

  Recombinant Proteins

• Source:

  HEK293 cells

• Purity:

  >90% as determined by SDS-PAGE.

• Buffer:

  PBS, pH7.4

• Shipping Conditions:

  Room Temp

• Storage Conditions:

  Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.

• Calculated Molecular Weight:

  10.4 kDa

• Applications Notes:

  This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 10.4 kDa. The protein migrates as 18-25 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

• NCBI Official Name:

  Prostate stem cell antigen

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Sakamoto H, et al. 2008. Nat Genet. 40 (6) :730-40.

• Background Reference 02:

  Jensen MM, et al. 2015. Neurobiol Aging. 36 (4) :1629-1638.

• Background Reference 03:

  Li E, et al. 2017. Prostate. 77 (16) :1563-1572.

• Other Product Names:

  PSCA, UNQ206, PRO232

• Tested Applications:

  WB

• Species:

  Human

• Physical Properties:

  Lyophilized

• CAS Number:

  9000-83-3