Tau-441 / 2N4R Recombinant Protein

• Background:

  Tau is a microtubule-associated protein, which encodes by the MAPT gene that located on chromosome 17q21. Tau Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. Hyperphosphorylation of the tau protein (tau inclusions, pTau) can result in the self-assembly of tangles of paired helical filaments and straight filaments, which are involved in the pathogenesis of Alzheimer's disease, frontotemporal dementia, and other tauopathies. Tau-441 is known as "2N4R, " "Isoform Tau-F, " "Tau-4" or "Tau 441", which consisting of 441 amino acid. Tau-441 is a potential therapeutic target for pathogenesis.

• NCBI Gene ID:

  4137

• Swiss Prot:

  P10636

• Accession Number:

  NP_005901.2

• Tag:

  His Tag

• Type:

  Recombinant Proteins

• Source:

  E. coli

• Purity:

  >90% as determined by reduced SDS-PAGE.

• Buffer:

  50 mM Tris, 150 mM NaCl, 1 mM TCEP, 1 mM EDTA, pH7.5

• Shipping Conditions:

  Room Temp

• Storage Conditions:

  Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.

• Calculated Molecular Weight:

  47.9 kDa

• Applications Notes:

  This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 47.9 kDa. The protein migrates as 60 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

• NCBI Official Name:

  Microtubule associated protein tau

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Yoshida H, et al. 2012. J. Neurochem. 120:165-176.

• Background Reference 02:

  Alonso A., et al. 2001.Proc. Natl. Acad. Sci. U.S.A.98 (12) : 6923–8

• Other Product Names:

  DDPAC, FTDP-17, MAPT, MSTD, MTBT1, Tau, PHF-tau, TAU

• Tested Applications:

  WB

• Species:

  Human

• Physical Properties:

  Lyophilized

• CAS Number:

  9000-83-3