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TAU Antibody

CAT: 0223-8077-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-8077-01Size:0.02 mg
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Background
The microtubial-associated protein TAU (MAPT), more commonly known as TAU, is is normally a highly soluble protein found predominantly in neurons (1), but accumulations of highly phosphorylated tau protein aggregates are observed in several neurodegenerative diseases including Alzheimer's disease, progressive supranuclear palsy, corticobasal degeneration, and frontotemporal lobar dementia. It was thought that these pathological tau aggregates were the toxic form of tau, but recent studies indicate that soluble and highly phosphorylated tau species are more closely associated with synaptic dysfunction and cell loss (2,3) . Mutations in the TAU gene have also been associated with several of these neurodegenerative diseases (4) .
NCBI Gene ID
4137
Swiss Prot
P10636
Accession Number
NP_058519
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Neuroscience
Purification
TAU antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1220 - SK-N-SH Cell Lysate
Concentration
1 mg/mL
Buffer
TAU antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
TAU antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.
Fragment
IgG
Specificity
TAU antibody is human, mouse and rat reactive. Multiple isoforms of TAU are known to exist; this antibody will only detect the two longest isoforms.
Symbol
TAU
Positive Control 2
Cat. No. 1463 - Rat Brain Tissue Lysate
NCBI Official Name
Microtubule-associated protein tau
NCBI Organism
Homo sapiens
Background Reference 01
Dotti CG, Banker GA, and Binder LI. The expression and distribution of the microtubule-associated proteins tau and microtubule-associated protein 2 in hippocampal neurons in the rat in situ and in cell culture. Neuroscience 1987; 23:121-30.
Background Reference 02
Hanger DP, Brion JP, Gallo JM, et al. Tau in Alzheimer's disease and Down's syndrome is insoluble and abnormally phosphorylated. Biochem. J. 1991; 275:99–104.
Background Reference 03
Rocher AB, Crimins JL, Amatrudo JM, et al. Structural and functional changes in tau mutant mice neurons are not linked to the presence of NFTs. Exp. Neurol. 2010; 223:385–93.
Background Reference 04
Galimberti D and Scarpini E. Genetics and biology of Alzheimer's disease and frontotemporal lobar degeneration. IInt. J. Clin. Exp. Med. 2010; 3:129-43.
Other Product Names
Microtubial-associated protein tau, MAPT, MAPTL, DDPAC, FTDP-17L, MSTD, MTBT1, MTBT2, PPND, PPP1R103
Tested Applications
ELISA, WB, IHC-P
Protein ID
294862261
Physical Properties
Liquid

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