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Tau Antibody

CAT: 0223-79-698Size: 0.1 mgDry Ice: NoHazardous: No
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CAT#:0223-79-698Size:0.1 mg
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Background
Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.
NCBI Gene ID
29477
Swiss Prot
P19332
Accession Number
NP_058908.2
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Tau antibody was raised against a peptide sequence around aa. 725-729 (T-G-S-I-D) derived from Rat Tau.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Neuroscience
Purification
Antibodies were purified by affinity-chromatography using epitope-specific peptide
Concentration
1 mg/mL
Buffer
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store antibody at -20˚ C for up to one year.
Calculated Molecular Weight
48 62 78 kDa
Specificity
This antibody detects endogenous level of total Tau protein.
Applications Notes
Western Blot: 1:500~1:1000
Symbol
Mapt
NCBI Official Name
Microtubule-associated protein tau
NCBI Organism
This antibody was raised against a peptide sequence around aa. 725-729 (T-G-S-I-D) derived from Rat Tau
Background Reference 01
Johnson, G. V. and Stoothoff, W. H. (2004) J. Cell Sci. 117, 5721-5729. Hanger, D. P. et al. (1998) J. Neurochem. 71, 2465-2476. Bramblett, G. T. et al. (1993) Neuron 10, 1089-1099.
Other Product Names
PTau, Mtapt, RNPTAU, MAPT, MTAPT, MTBT1, Neurofibrillary tangle protein, PHF-tau
Tested Applications
WB
Protein ID
158303318
Physical Properties
Liquid

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