S100A10 Recombinant Protein

• Background:

  S100 calcium-binding protein A10 (S100A10), a member of the S100 family of proteins containing two EF-hand calcium-binding motifs, is also known as protein S100-A10, calpactin I light chain, cellular ligand of annexin II, p10 protein and p11, which can be found as a free monomer, a homodimer, or a heterotetramer composed of a p11 dimer complex with two molecules of annexin II. S100A10 is an integral part of cellular structural scaffolding that interacts with plasma membrane proteins through its association with annexin II. S100A10 also works together with cytosolic and peripheral membrane-associated proteins such as AHNAK in the development of the intracellular membrane. Furthermore, S100A10 has been implicated in the transportation of proteins involved in mood regulation, nociception, and cell polarization. Complexed with the annexin II, S100A10 binds receptor and channel proteins and guides them to the cell surface, resulting in increased membrane localization and consequent magnified functional expression of these proteins.

• NCBI Gene ID:

  6281

• Swiss Prot:

  P60903

• Accession Number:

  AAH15973

• Tag:

  His Tag

• Type:

  Recombinant Proteins

• Source:

  E. coli

• Field of Research:

  Other

• Purity:

  >95% as determined by SDS-PAGE.

• Buffer:

  50 mM Tris,150 mM NaCl, pH8.0

• Shipping Conditions:

  Room Temp

• Storage Conditions:

  Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -71˚ C. Avoid repeated freeze-thaw cycles.

• Calculated Molecular Weight:

  12 kDa

• Applications Notes:

  This recombinant protein can be used for WB. For research use only.

• NCBI Official Name:

  S100 calcium binding protein A10

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Harder T., et al., 1992, Gene. 113 (2) :269-74.

• Background Reference 02:

  Choudhary C., et al., 2009, Science 325:834-840.

• Background Reference 03:

  Rety S., et al., 1999, Nat. Struct. Biol. 6:89-95.

• Other Product Names:

  S100A10, p11, p10, ANX2LG, CAL1L, CLP11

• Tested Applications:

  WB

• Species:

  Human

• Physical Properties:

  Lyophilized

• CAS Number:

  9000-83-3