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HER4 Recombinant Protein

CAT: 0223-96-286Size: 0.1 mgDry Ice: NoHazardous: No
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CAT#:0223-96-286Size:0.1 mg
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Background
Receptor tyrosine-protein kinase erbB-4 (ErbB4) is also known as Her4, is a single-pass type I transmembrane glycoprotein that is a member of the ErbB family of tyrosine kinase receptors. ErbB family members serve as receptors for the epidermal growth factor (EGF) family of growth factors. ErbB4 is expressed in normal skeletal muscle, heart, pituitary, brain and several breast carcinomas. ERBB4 contains multiple furin-like cysteine rich domains, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins-2 and -3, heparin-binding EGF-like growth factor and betacellulin. Ligand binding induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. ErbB4 appears to play important roles in neuronal development, development of the heart and cancer. ERBB4 has been shown to interact with: DLG4, NRG1, STAT5A and YAP1. Mutations in this gene have been associated with cancer. Other single-nucleotide polymorphisms and a risk haplotype have been linked to schizophrenia.
CAS Number
9000-83-3
NCBI Gene ID
2066
Swiss Prot
Q15303
Accession Number
NP_001036064.1
Tag
C-Fc Tag
Type
Recombinant Proteins
Source
HEK293 cells
Field of Research
Cancer, Signal Transduction
Purity
>90% as determined by SDS-PAGE.
Buffer
PBS, pH7.4
Shipping Conditions
Room Temp
Storage Conditions
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Calculated Molecular Weight
96 kDa
Applications Notes
This recombinant protein can be used for WB. For research use only.
NCBI Official Name
V-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4
NCBI Organism
Homo sapiens
Background Reference 01
Garcia R A., et al., 2000, (UNITED STATES) 97 (7) : 3596–601.
Background Reference 02
Huang, Y Z., et al., 2000, Neuron (UNITED STATES) 26 (2) : 443–55.
Background Reference 03
Williams Christopher C., et al., 2004, J. Cell Biol. (United States) 167 (3) : 469–78.
Background Reference 04
Schulze Waltraud X., et al., 2005, Mol. Syst. Biol. (England) 1 (1) : 2005.0008.
Other Product Names
HER4, ErbB4, MGC138404, p180erbB4
Tested Applications
WB
Species
Human
Physical Properties
Lyophilized

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