Her2 / ErbB2 Recombinant Protein

• Background:

  Human Epidermal growth factor Receptor 2 (HER2) is also called ERBB2, HER-2, HER-2 /neu, NEU, NGL, TKR1 and c-erb B2, and is a protein giving higher aggressiveness in breast cancers. It is a member of the ErbB protein family, more commonly known as the epidermal growth factor receptor family. HER2 is a cell membrane surface-bound receptor tyrosine kinase and is normally involved in the signal transduction pathways leading to cell growth and differentiation. HER2 is thought to be an orphan receptor, with none of the EGF family of ligands able to activate it. Approximately 30% of breast cancers have an amplification of the HER2 gene or overexpression of its protein product. Overexpression of this receptor in breast cancer is associated with increased disease recurrence and worse prognosis. HER2 appears to play roles in development, cancer, communication at the neuromuscular junction and regulation of cell growth and differentiation .

• NCBI Gene ID:

  2064

• Swiss Prot:

  P04626

• Accession Number:

  NP_004439.2

• Tag:

  Tag Free

• Type:

  Recombinant Proteins

• Source:

  HEK293 cells

• Field of Research:

  Immunology

• Purity:

  >95% as determined by SDS-PAGE.

• Buffer:

  PBS, pH7.4

• Shipping Conditions:

  Room Temp

• Storage Conditions:

  Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.

• Calculated Molecular Weight:

  70.1 kDa

• Applications Notes:

  This protein carries no "tag". The protein has a calculated MW of 70.1 kDa. The protein migrates as 90-100 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

• NCBI Official Name:

  Erb-b2 receptor tyrosine kinase 2

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Kanai, Y. et. al., 1995, Biochem. Biophys. Res. Commun.208:1067.

• Background Reference 02:

  Codony-Seeervat, J. et al., 1999, Cancer Res. 59: 1196-1201.

• Background Reference 03:

  Tzahar, E. et al., 1998, Biochim. Biophys. Acta. 1377: 25-37.

• Background Reference 04:

  Kermit, L. et al, 1999, J. Biol. Chem. 274: 5263-5266.

• Other Product Names:

  ERBB2, CD340, HER-2/neu, HER2, MLN19, NEU, NGL, TKR1

• Tested Applications:

  ELISA, WB

• Species:

  Human

• Physical Properties:

  Lyophilized

• CAS Number:

  9000-83-3