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HER2 Recombinant Protein

CAT: 0223-96-279Size: 0.1 mgDry Ice: NoHazardous: No
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CAT#:0223-96-279Size:0.1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Human Epidermal growth factor Receptor 2 (HER2) is also called ERBB2, HER-2, HER-2/neu, NEU, NGL, TKR1 and c-erb B2, and is a protein giving higher aggressiveness in breast cancers. It is a member of the ErbB protein family, more commonly known as the epidermal growth factor receptor family. HER2 is a cell membrane surface-bound receptor tyrosine kinase and is normally involved in the signal transduction pathways leading to cell growth and differentiation. HER2 is thought to be an orphan receptor, with none of the EGF family of ligands able to activate it. Approximately 30% of breast cancers have an amplification of the HER2 gene or overexpression of its protein product. Overexpression of this receptor in breast cancer is associated with increased disease recurrence and worse prognosis. HER2 appears to play roles in development, cancer, communication at the neuromuscular junction andregulation of cell growth and differentiation.
CAS Number
9000-83-3
NCBI Gene ID
13866
Swiss Prot
P70424
Accession Number
AAH53078.1
Tag
His Tag
Type
Recombinant Proteins
Source
HEK293 cells
Field of Research
Cancer, Signal Transduction
Purity
>95% as determined by SDS-PAGE.
Buffer
PBS, pH7.4
Shipping Conditions
Room Temp
Storage Conditions
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Calculated Molecular Weight
70.6 kDa
Applications Notes
This recombinant protein can be used for WB. For research use only.
NCBI Official Name
V-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
NCBI Organism
Mus musculus
Background Reference 01
Kanai, Y. et. al., 1995, Biochem. Biophys. Res. Commun.208:1067.
Background Reference 02
Codony-Seeervat, J. et al., 1999, Cancer Res. 59: 1196-1201.
Background Reference 03
Tzahar, E. et al., 1998, Biochim. Biophys. Acta. 1377: 25-37.
Background Reference 04
Kermit, L. et al, 1999, J. Biol. Chem. 274: 5263-5266.
Other Product Names
ERBB2, CD340, HER-2/neu, HER2, MLN19, NEU, NGL, TKR1
Tested Applications
WB
Species
Mouse
Physical Properties
Lyophilized

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