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PCSK9 Recombinant Protein

CAT: 0223-96-583Size: 0.1 mgDry Ice: NoHazardous: No
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CAT#:0223-96-583Size:0.1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is also known as NARC1 (neural apoptosis regulated convertase), is a newly identified subtilase belonging to the peptidase S8 subfamily. Mouse PCSK9 is synthesized as a soluble zymogen, and undergoes autocatalytic intramolecular processing in the endoplasmic reticulum, resulting in the cleavage of its propeptide that remains associated with the secreted active enzyme with a broad alkaline pH optimum. This protein plays a major regulatory role in cholesterol homeostasis. PCSK9 binds to the epidermal growth factor-like repeat A (EGF-A) domain of the low-density lipoprotein receptor (LDLR), inducing LDLR degradation. PCSK9 may also have a role in the differentiation of cortical neurons. Mutations in this gene have been associated with a rare form of autosomal dominant familial hypercholesterolemia (HCHOLA3) .
CAS Number
9000-83-3
NCBI Gene ID
100102
Swiss Prot
Q80W65
Accession Number
AAH38085.1
Tag
His Tag
Type
Recombinant Proteins
Source
HEK293 cells
Purity
>97% as determined by SDS-PAGE.
Buffer
PBS, pH7.4
Shipping Conditions
Room Temp
Storage Conditions
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Calculated Molecular Weight
72 kDa
Applications Notes
This recombinant protein can be used for WB. For research use only.
NCBI Official Name
Proprotein convertase subtilisin/kexin type 9
NCBI Organism
Mus musculus
Background Reference 01
Seidah NG, et al., Proc. Natl. Acad. Sci. U.S.A. 100 (3) : 928–33.
Background Reference 02
Abifadel, M. et al., 2003, Nat. Genet. 34: 154-156.
Background Reference 03
Dubuc G. et al., 2004, Arterioscler. Thromb. Vasc. Biol. 24 (8) : 1454–9.
Other Product Names
PCSK9, FH3, HCHOLA3, LDLCQ1, NARC1, PC9
Tested Applications
WB
Species
Mouse
Physical Properties
Lyophilized

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