PCSK9 Antibody

• Background:

  This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an autocatalytic processing event with its prosegment in the ER and is constitutively secreted as an inactive protease into the extracellular matrix and trans-Golgi network. It is expressed in liver, intestine and kidney tissues and escorts specific receptors for lysosomal degradation. It plays a role in cholesterol and fatty acid metabolism. Mutations in this gene have been associated with autosomal dominant familial hypercholesterolemia. Alternative splicing results in multiple transcript variants.

• NCBI Gene ID:

  255738

• Swiss Prot:

  Q8NBP7

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  A synthetic peptide corresponding to a sequence within amino acids 600 to the C-terminus of human PCSK9 (NP_777596.2) .

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Apoptosis, Cancer, Cell Cycle, Neuroscience, Signal Transduction, Stem Cell

• Purification:

  Affinity purification

• Positive Control:

  SW480

• Concentration:

  Batch dependent

• Buffer:

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  Observed: 60kDa/72kDa

• Fragment:

  IgG

• Symbol:

  PCSK9

• NCBI Official Name:

  Proprotein convertase subtilisin/kexin type 9

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  Neural apoptosis regulated convertase 1, hypercholesterolemia, autosomal dominant 3, NARC1, NARC-1, HCHOLA3, FH3, proprotein convertase subtilisin/kexin type 9, PCSK9, PSEC0052

• Tested Applications:

  WB, IHC

• Physical Properties:

  Liquid