PCSK9 Antibody

• Background:

  PCSK9 is a proprotein convertase belonging to the proteinase K subfamily of the secretory subtilase family. This protein is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in the endoplasmic reticulum. The protein may function as a proprotein convertase. The protein plays a role in cholesterol homeostasis and may have a role in the differentiation of cortical neurons.

• NCBI Gene ID:

  255738

• Swiss Prot:

  Q8NBP7

• Accession Number:

  Q8NBP7

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This PCSK9 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 479-508 amino acids from the C-terminal region of human PCSK9.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cell Cycle, Obesity, Signal Transduction

• Purification:

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  74 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  PCSK9

• NCBI Official Name:

  Proprotein convertase subtilisin/kexin type 9

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Abifadel, M., Rabes, J.P. Hum. Mutat. 30 (7), E682-E691 (2009)

• Background Reference 02:

  McNutt, M.C., Kwon, H.J. J. Biol. Chem. 284 (16), 10561-10570 (2009)

• Background Reference 03:

  Shioji, K., Mannami, T. J. Hum. Genet. 49 (2), 109-114 (2004)

• Background Reference 04:

  Abifadel, M., Varret, M. Nat. Genet. 34 (2), 154-156 (2003)

• Other Product Names:

  Proprotein convertase subtilisin/kexin type 9, 3421-, Neural apoptosis-regulated convertase 1, NARC-1, Proprotein convertase 9, PC9, Subtilisin/kexin-like protease PC9, PCSK9, NARC1

• Tested Applications:

  WB, IHC-P, Flow

• Protein ID:

  317373487

• Physical Properties:

  Liquid