PCSK9 Recombinant Protein

• Background:

  Proprotein convertase subtilisin/kexin type 9 (PCSK9) is also known as NARC1 (neural apoptosis regulated convertase), is a newly identified subtilase belonging to the peptidase S8 subfamily. Mouse PCSK9 is synthesized as a soluble zymogen, and undergoes autocatalytic intramolecular processing in the endoplasmic reticulum, resulting in the cleavage of its propeptide that remains associated with the secreted active enzyme with a broad alkaline pH optimum. This protein plays a major regulatory role in cholesterol homeostasis. PCSK9 binds to the epidermal growth factor-like repeat A (EGF-A) domain of the low-density lipoprotein receptor (LDLR), inducing LDLR degradation. PCSK9 may also have a role in the differentiation of cortical neurons. Mutations in this gene have been associated with a rare form of autosomal dominant familial hypercholesterolemia (HCHOLA3) .

• Swiss Prot:

  G7NVZ1

• Tag:

  His Tag

• Type:

  Recombinant Proteins

• Source:

  HEK293 cells

• Field of Research:

  Immunology

• Buffer:

  PBS, pH7.4

• Shipping Conditions:

  Room Temp

• Storage Conditions:

  Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.

• Calculated Molecular Weight:

  73.2 kDa

• Applications Notes:

  This recombinant protein can be used for WB. For research use only.

• NCBI Organism:

  Macaca fascicularis

• Background Reference 01:

  Seidah NG, et al., Proc. Natl. Acad. Sci. U.S.A. 100 (3) : 928–33.

• Background Reference 02:

  Abifadel, M. et al., 2003, Nat. Genet. 34: 154-156.

• Background Reference 03:

  Dubuc G. et al., 2004, Arterioscler. Thromb. Vasc. Biol. 24 (8) : 1454–9.

• Other Product Names:

  PCSK9, FH3, HCHOLA3, LDLCQ1, NARC1, PC9

• Tested Applications:

  WB

• Species:

  Cynomolgus monkey

• Physical Properties:

  Lyophilized

• CAS Number:

  9000-83-3