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CD27 Recombinant Protein

CAT: 0223-90-391Size: 50 µgDry Ice: NoHazardous: No
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CAT#:0223-90-391Size:50 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
CD27 (TNFRSF7) is a member of the TNF-receptor superfamily limited to cells of the lymphoid lineage and exists as both a dimeric glycoprotein on the cell surface and as a soluble protein in serum. As a T and B cell co-stimulatory molecule, the activity of CD27 is governed by its TNF-like ligand CD70 on lymphocytes and dendritic cells. The CD27-CD70 interaction is required for Th1 generation responses to differentiation signals and long-term maintenance of T cell immunity, and meanwhile, plays a key role in regulating B cell differentiation, activation and immunoglobulin synthesis. The CD27 receptor transduces signals and subsequently leads to the activation of NF-kappaB and MAPK8/JNK, mediated by the adaptor proteins TRAF2 and TRAF5. In addition, the proapoptotic protein SIVA is capable of binding the cytoplasmic tail of CD27 and exerts action in the process of apoptosis.
CAS Number
9000-83-3
NCBI Gene ID
939
Swiss Prot
Q9JHJ8
Accession Number
AAH12160
Tag
His Tag
Type
Recombinant Proteins
Source
E. coli
Field of Research
Apoptosis, Cancer, Growth Factors, Immunology, Signal Transduction, Stem Cell
Buffer
Lyophilized from 0.2um-filtered solution in 50mM Tris-HCl buffer (pH 8.0) and 500mM NaCl. Reconstitute in sterile water not less than 100 μ g/ml, which can then be further diluted to other aqueous solutions.
Shipping Conditions
Room Temp
Storage Conditions
Stable for at least 1 year after receipt when stored at -20˚ C. Working aliquots are stable for up to 3 months when stored at -20˚ C.
Applications Notes
This recombinant proteins is for research use only.
NCBI Official Name
CD27 molecule
NCBI Organism
Homo sapiens
Other Product Names
T Cell Activation Antigen CD27, T14, TNFRSF7, Tumor Necrosis Factor Receptor Superfamily Member 7, S152
Species
Human
Protein ID
15082491
Physical Properties
Lyophilized

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