CD27 Recombinant Protein

• Background:

  CD27 (TNFRSF7) is a member of the TNF-receptor superfamily limited to cells of the lymphoid lineage and exists as both a dimeric glycoprotein on the cell surface and as a soluble protein in serum. As a T and B cell co-stimulatory molecule, the activity of CD27 is governed by its TNF-like ligand CD70 on lymphocytes and dendritic cells. The CD27-CD70 interaction is required for Th1 generation responses to differentiation signals and long-term maintenance of T cell immunity, and meanwhile, plays a key role in regulating B cell differentiation, activation and immunoglobulin synthesis. The CD27 receptor transduces signals and subsequently leads to the activation of NF-kappaB and MAPK8/JNK, mediated by the adaptor proteins TRAF2 and TRAF5. In addition, the proapoptotic protein SIVA is capable of binding the cytoplasmic tail of CD27 and exerts action in the process of apoptosis.

• NCBI Gene ID:

  939

• Swiss Prot:

  Q9JHJ8

• Accession Number:

  AAH12160

• Tag:

  His Tag

• Type:

  Recombinant Proteins

• Source:

  E. coli

• Field of Research:

  Apoptosis, Cancer, Growth Factors, Immunology, Signal Transduction, Stem Cell

• Buffer:

  Lyophilized from 0.2um-filtered solution in 50mM Tris-HCl buffer (pH 8.0) and 500mM NaCl. Reconstitute in sterile water not less than 100 μ g/ml, which can then be further diluted to other aqueous solutions.

• Shipping Conditions:

  Room Temp

• Storage Conditions:

  Stable for at least 1 year after receipt when stored at -20˚ C. Working aliquots are stable for up to 3 months when stored at -20˚ C.

• Applications Notes:

  This recombinant proteins is for research use only.

• NCBI Official Name:

  CD27 molecule

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  T Cell Activation Antigen CD27, T14, TNFRSF7, Tumor Necrosis Factor Receptor Superfamily Member 7, S152

• Species:

  Human

• Protein ID:

  15082491

• Physical Properties:

  Lyophilized

• CAS Number:

  9000-83-3