Products for Research Use Only

PD-L1 Recombinant Protein

CAT: 0223-97-020Size: 0.1 mgDry Ice: NoHazardous: No
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CAT#:0223-97-020Size:0.1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Programmed cell death 1 ligand 1 (PDL1) is also known as B7-H, B7H1, MGC142294, MGC142296, PD-L1, PDCD1L1 and PDCD1LG1, which is a member of the growing B7 family of immune molecules and is involved in the regulation of cellular and humoral immune responses.PDL1 is a cell surface immunoglobulin superfamily with two Ig-like domains within the extracellular region and a short cytoplasmic domain. This protein is broadly expressed in the majority of peripheral tissues as well as hematopoietic cells. Interaction between PDL1 and its receptors belonging to the CD28 family of molecules provide both stimulatory and inhibitory signals in regulating T cell activation and tolerance. PDL1 may inhibit ongoing T-cell responses by inducing apoptosis and arresting cell-cycle progression.
CAS Number
9000-83-3
NCBI Gene ID
60533
Accession Number
NP_068693
Tag
Mouse IgG2a Fc tag
Type
Recombinant Proteins
Source
HEK293 cells
Field of Research
Immunology
Buffer
PBS, pH7.4
Shipping Conditions
Room Temp
Storage Conditions
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Calculated Molecular Weight
51.8 kDa
Applications Notes
This recombinant protein can be used for WB. For research use only.
NCBI Official Name
Programmed cell death 1 ligand 1
NCBI Organism
Mus musculus
Background Reference 01
Dong H., et al., 1999, Nat. Med. 5:1365-1369.
Background Reference 02
Freeman G.J., et al., 2000, J. Exp. Med. 192:1027-1034.
Background Reference 03
Nishimura H., et al., 2001, Trends in Immunology 22:265.
Other Product Names
PD-L1, CD274, B7-H1, PDCD1L1, PDCD1LG1
Tested Applications
WB
Species
Mouse
Physical Properties
Lyophilized