PD-L1 / B7-H1 Recombinant Protein

• Background:

  Programmed cell death 1 ligand 1 (PDL1) is also known as B7-H, B7H1, MGC142294, MGC142296, PD-L1, PDCD1L1 and PDCD1LG1, which is a member of the growing B7 family of immune molecules and is involved in the regulation of cellular and humoral immune responses.PDL1 is a cell surface immunoglobulin superfamily with two Ig-like domains within the extracellular region and a short cytoplasmic domain. This protein is broadly expressed in the majority of peripheral tissues as well as hematopoietic cells. Interaction between PDL1 and its receptors belonging to the CD28 family of molecules provide both stimulatory and inhibitory signals in regulating T cell activation and tolerance. PDL1 may inhibit ongoing T-cell responses by inducing apoptosis and arresting cell-cycle progression.

• NCBI Gene ID:

  100357106

• Accession Number:

  XP_008253343.1

• Tag:

  His Tag

• Type:

  Recombinant Proteins

• Source:

  HEK293 cells

• Purity:

  >90% as determined by SDS-PAGE.

• Buffer:

  PBS, pH7.4

• Shipping Conditions:

  Room Temp

• Storage Conditions:

  Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.

• Calculated Molecular Weight:

  27.1 kDa

• Applications Notes:

  This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 27.1 kDa. The protein migrates as 32-44 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

• NCBI Official Name:

  CD274 molecule

• NCBI Organism:

  Oryctolagus cuniculus

• Background Reference 01:

  Dong H., et al., 1999, Nat. Med. 5:1365-1369.

• Background Reference 02:

  Freeman G.J., et al., 2000, J. Exp. Med. 192:1027-1034.

• Background Reference 03:

  Nishimura H., et al., 2001, Trends in Immunology 22:265.

• Other Product Names:

  PD-L1, CD274, B7-H1, PDCD1L1, PDCD1LG1

• Tested Applications:

  WB

• Species:

  Rabbit

• Physical Properties:

  Lyophilized

• CAS Number:

  9000-83-3