PAPS synthase 1 Recombinant Protein

• Background:

  PAPSS1 is a bifunctional enzyme with both ATP sulfurylase and APS kinase activity. In the N-terminal section, it belongs to the APS kinase family; while the C-terminal section belongs to the sulfate adenylyltransferase family. PAPSS1 can be inhibited by chlorate, and is expressed in many tissues, such as high endothelial venules (HEV) cells and in cartilage. PAPSS1 mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5'-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3'-phosphoadenylylsulfate. In mammals, PAPS is the sole source of sulfate; APS appears to be only an intermediate in the sulfate-activation pathway. PAPSS1 also involved in the biosynthesis of sulfated L-selectin ligands in endothelial cells.

• NCBI Gene ID:

  9061

• Swiss Prot:

  O43252

• Accession Number:

  O43252

• Tag:

  C-6 His tag

• Type:

  Recombinant Proteins

• Source:

  Human Cells

• Field of Research:

  Cell Cycle

• Buffer:

  Supplied as a 0.2 um filtered solution of 20mM Tris-HCl buffer (pH 8.0), 100mM NaCl and 20% glycerol. It is not recommended to reconstitute to a concentration less than 100 ug/ml.

• Shipping Conditions:

  Dry Ice

• Calculated Molecular Weight:

  71.9 kD

• Applications Notes:

  This recombinant protein can be used for biological assays. For research use only.

• NCBI Official Name:

  3'-phosphoadenosine 5'-phosphosulfate synthase 1

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1, PAPS synthase 1, PAPSS 1, Sulfurylase kinase 1, SK 1, ATPSK1, PAPSS, PAPSS1

• Species:

  Human

• Physical Properties:

  Liquid

• CAS Number:

  9000-83-3