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PAPS synthase 1 Recombinant Protein

CAT: 0223-92-367Size: 0.05 mgDry Ice: YesHazardous: No
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CAT#:0223-92-367Size:0.05 mg
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Background
PAPSS1 is a bifunctional enzyme with both ATP sulfurylase and APS kinase activity. In the N-terminal section, it belongs to the APS kinase family; while the C-terminal section belongs to the sulfate adenylyltransferase family. PAPSS1 can be inhibited by chlorate, and is expressed in many tissues, such as high endothelial venules (HEV) cells and in cartilage. PAPSS1 mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5'-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3'-phosphoadenylylsulfate. In mammals, PAPS is the sole source of sulfate; APS appears to be only an intermediate in the sulfate-activation pathway. PAPSS1 also involved in the biosynthesis of sulfated L-selectin ligands in endothelial cells.
CAS Number
9000-83-3
NCBI Gene ID
9061
Swiss Prot
O43252
Accession Number
O43252
Tag
C-6 His tag
Type
Recombinant Proteins
Source
Human Cells
Field of Research
Cell Cycle
Buffer
Supplied as a 0.2 um filtered solution of 20mM Tris-HCl buffer (pH 8.0), 100mM NaCl and 20% glycerol. It is not recommended to reconstitute to a concentration less than 100 ug/ml.
Shipping Conditions
Dry Ice
Calculated Molecular Weight
71.9 kD
Applications Notes
This recombinant protein can be used for biological assays. For research use only.
NCBI Official Name
3'-phosphoadenosine 5'-phosphosulfate synthase 1
NCBI Organism
Homo sapiens
Other Product Names
Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1, PAPS synthase 1, PAPSS 1, Sulfurylase kinase 1, SK 1, ATPSK1, PAPSS, PAPSS1
Species
Human
Physical Properties
Liquid

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