Argininosuccinate Synthase Recombinant Protein

• Background:

  Argininosuccinate Synthase (ASS1) is an urea cycle enzyme with a tetrameric structure composed of identical subunits. ASS1 is involved in the synthesis of arginine and catalyzes that condensation of citrulline and aspartate to argininosuccinate using ATP. ASS1 is important to the urea cycle as it catalyzes the important second last step in the arginine biosynthetic pathway. ASS1 mainly expressed in periportal hepatocytes, but also in most other body tissues. A deficiency of ASS1 causes citrullinemia (CTLN1), an autosomal recessive disease which is characterized by severe vomiting spells and mental retardation.

• NCBI Gene ID:

  445

• Swiss Prot:

  P00966

• Accession Number:

  P00966

• Tag:

  N-6 His tag

• Type:

  Recombinant Proteins

• Source:

  E. coli

• Field of Research:

  Homeostasis, Obesity, Signal Transduction

• Buffer:

  Supplied as a 0.2 um filtered solution of 20mM PB, 150mM NaCl, 50mM Imidazole, 1mM DTT, 40% Glycerol, pH 7.5. It is not recommended to reconstitute to a concentration less than 100 ug/ml.

• Shipping Conditions:

  Dry Ice

• Calculated Molecular Weight:

  42.8 kD

• Applications Notes:

  This recombinant protein can be used for biological assays. For research use only.

• NCBI Official Name:

  Argininosuccinate synthase 1

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  Argininosuccinate Synthase, Citrulline--Aspartate Ligase, ASS1, ASS

• Species:

  Human

• Protein ID:

  530427178

• Physical Properties:

  Liquid

• CAS Number:

  9000-83-3