MAPT-D Recombinant Protein

• Background:

  Microtubule-Associated Protein TAU is abundantly expressed in neurons of the central nervous system and less commonly expressed elsewhere, but is also expressed at very low levels in CNS astrocytes and oligodendrocytes. Tau interacts with tubulin to stabilize microtubules and promotes tubulin assembly into microtubules. The C-terminus of TAU binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau acts as a linker protein. When tau is defective, and no longer stabilize microtubules properly, it can result in dementias such as Alzheimer's disease and other tauopathies.

• NCBI Gene ID:

  4137

• Swiss Prot:

  P10636

• Accession Number:

  P10636

• Tag:

  C-6 His tag

• Type:

  Recombinant Proteins

• Source:

  E. coli

• Field of Research:

  Neuroscience, Other

• Buffer:

  Lyophilized from a 0.2 um filtered solution of 20mM PB, 150mM NaCl, pH 7.4. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in ddH2O.

• Shipping Conditions:

  Room Temp

• Calculated Molecular Weight:

  15.37 kD

• Applications Notes:

  This recombinant protein can be used for biological assays. For research use only.

• NCBI Official Name:

  Microtubule associated protein tau

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  Microtubule-Associated Protein Tau, Neurofibrillary Tangle Protein, Paired Helical Filament-Tau, PHF-Tau, MAPT, MAPTL, MTBT1, TAU, Tau-D

• Species:

  Human

• Physical Properties:

  Lyophilized

• CAS Number:

  9000-83-3