VEGF-D Recombinant Protein

• Background:

  VEGF-D, a member of the VEGF/PDGF family of structurally related proteins, is a potent angiogenic cytokine. It promotes endothelial cell growth, promotes lymphangiogesis, and can also affect vascular permeability. VEGF-D is highly expressed in the lung, heart, small intestine and fetal lung, and at lower levels in the skeletal muscle, colon, and pancreas. It forms cell surfaced-associated non-covalent disulfide linked homodimers, and can bind and activate both VEGFR-2 (flk1) and VEGFR-3 (flt4) receptors. During embryogenesis, VEGF-D may play a role in the formation of the venous and lymphatic vascular systems. It also participates in the growth and maintenance of differentiated lymphatic endothelium in adults. Both VEGF-C and VEGF-D are over-expressed in certain cancers, and the resulting elevated levels of VEGF-C or VEGF-D tend to correlate with increased lymphatic metastasis. Recombinant human VEGF-D is a 13.1 kDa non-disulfide linked homodimeric protein consisting of two 117 amino acid polypeptide chains. Due to glycosylation the protein migrates as a 20.0-22.0 kDa band under non-reducing condition.

• NCBI Gene ID:

  2277

• Swiss Prot:

  O43915

• Accession Number:

  NP_004460.1

• Type:

  Recombinant Proteins

• Source:

  HEK293 cells

• Field of Research:

  Cancer, Signal Transduction

• Shipping Conditions:

  Room Temp

• Storage Conditions:

  The lyophilized VEGF-D recombinant protein is stable for at least 2 years from date of receipt at -20˚ C. Reconstituted VEGF-D is stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚ C. As with any protein, exposing VEGF-D recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.

• NCBI Official Name:

  C-fos induced growth factor (vascular endothelial growth factor D)

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  VEGFD, VEGF-D, VEGFD, Vascular endothelial growth factor D, c-Fos-induced growth factor

• Species:

  Human

• Protein ID:

  4758378

• Physical Properties:

  Lyophilized