MGMT Recombinant Protein

• Background:

  MGMT belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. MGMT involved in the cellular defense against the biological effects of O6-methylguanine in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. MGMT catalyzes the chemical reaction: DNA (containing 6-O-methylguanine) and proteinL-cysteine into DNA (without 6-O-methylguanine) and protein S-methyl-L-cysteine.

• NCBI Gene ID:

  4255

• Swiss Prot:

  P16455

• Accession Number:

  P16455

• Tag:

  N-6 His tag

• Type:

  Recombinant Proteins

• Source:

  E. coli

• Field of Research:

  Other

• Buffer:

  Supplied as a 0.2 um filtered solution of 20mMTrisHCl,1mM EDTA, pH 8.0 . It is not recommended to reconstitute to a concentration less than 100 ug/ml.

• Shipping Conditions:

  Dry Ice

• Calculated Molecular Weight:

  23.8 kD

• Applications Notes:

  This recombinant protein can be used for biological assays. For research use only.

• NCBI Official Name:

  O-6-methylguanine-DNA methyltransferase

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  Methylated-DNA--protein-cysteine methyltransferase, 6-O-methylguanine-DNAmethyltransferase, O-6-methylguanine-DNA-alkyltransferase, MGMT

• Species:

  Human

• Protein ID:

  530394832

• Physical Properties:

  Liquid

• CAS Number:

  9000-83-3