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MGMT Antibody

CAT: 0223-62-838Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-62-838Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
MGMT is involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. This protein repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction: the protein is irreversibly inactivated.
NCBI Gene ID
4255
Swiss Prot
P16455
Accession Number
P16455
Host
Rabbit
Reactivity
Human
Immunogen
This MGMT antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 156-182 amino acids from the C-terminal region of human MGMT.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
22 kDa
Fragment
Rabbit Ig
Symbol
MGMT
NCBI Official Name
Methylated-DNA--protein-cysteine methyltransferase
NCBI Organism
Homo sapiens
Background Reference 01
Kim, J.I., Suh, J.T. Hum. Pathol. 40 (7), 934-941 (2009)
Background Reference 02
Chen, S.P., Chiu, S.C. Genet Test Mol Biomarkers 13 (1), 67-71 (2009)
Background Reference 03
Slupphaug, G., Lettrem, I. Carcinogenesis 13 (10), 1769-1773 (1992)
Background Reference 04
Lee, S.M., Crowther, D. Br. J. Cancer 66 (2), 331-336 (1992)
Other Product Names
Methylated-DNA--protein-cysteine methyltransferase, 6-O-methylguanine-DNA methyltransferase, MGMT, O-6-methylguanine-DNA-alkyltransferase, MGMT
Tested Applications
WB, IHC-P, Flow
Protein ID
127069
Physical Properties
Liquid

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