CD117 Recombinant Protein

CAT: 0223-96-839Size: 0.1 mgDry Ice: NoHazardous: No
CAT#:0223-96-839Size:0.1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Mast/stem cell growth factor receptor Kit (c-Kit), a member of the protein kinase superfamily, Tyr protein kinase family and CSF-1/PDGF receptor subfamily, is also known as piebald trait protein (PBT), p145 c-kit, tyrosine-protein kinase Kit and CD117, which contains five Ig-like C2-type (immunoglobulin-like) domains and one protein kinase domain. CD117 acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, CD117 can activate several signaling pathways. Furthermore, Activated KIT promotes phosphorylation of the protein phosphatases PTPN6/SHP-1 and PTPRU, and of the transcription factors STAT1, STAT3, STAT5A and STAT5B.
CAS Number
9000-83-3
NCBI Gene ID
3815
Swiss Prot
P10721-2
Accession Number
P10721-2
Tag
Fc Tag
Type
Recombinant Proteins
Source
HEK293 cells
Field of Research
Immunology
Buffer
Tris with Glycine, Arginine and NaCl, pH7.5
Shipping Conditions
Room Temp
Storage Conditions
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Calculated Molecular Weight
81.9 kDa
Applications Notes
This recombinant protein can be used for E, WB. For research use only.
NCBI Official Name
Mast/stem cell growth factor receptor Kit
NCBI Organism
Homo sapiens
Background Reference 01
Neumann I., et al., 2010, Pediatr. Blood Cancer 55:464-470.
Background Reference 02
Blume-Jensen P., et al., 1994, J. Biol. Chem. 269:21793-21802.
Background Reference 03
Sun J., et al.,2009, J. Biol. Chem. 284:11039-11047.
Other Product Names
CD117, SCFR, c-Kit, KIT
Tested Applications
ELISA, WB
Species
Human
Physical Properties
Lyophilized

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