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CD117/KIT Recombinant Protein

CAT: 0384-NCP0253-01Size: 500 µgDry Ice: NoHazardous: No
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CAT#:0384-NCP0253-01Size:500 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
C-Kit is a member of the subfamily of receptor tyrosine kinases that includes PDGF, CSF-1, and FLT3/flk-2 receptors. It plays a critical role in activation and growth in a number of cell types including hematopoietic stem cells, mast cells, melanocytes, and germ cells. Upon binding with its stem cell factor (SCF) ligand, c-Kit undergoes dimerization/oligomerization and autophosphorylation. Activation of c-Kit results in the recruitment and tyrosine phosphorylation of downstream SH2-containing signaling components including PLCγ, the p85 subunit of PI3 kinase, SHP2, and CrkL. Molecular lesions that impair the kinase activity of c-Kit are associated with a variety of developmental disorders, and mutations that constitutively activate c-Kit can lead to pathogenesis of mastocytosis and gastrointestinal stromal tumors. Tyr719 is located in the kinase insert region of the catalytic domain. c-Kit phosphorylated at Tyr719 binds to the p85 subunit of PI3 kinase in vitro and in vivo.
CAS Number
9000-83-3
Swiss Prot
P10721
Modification Site
NdeI-XhoI
Expression System
Pet-22b (+)
Tag
His-tag
Purity
Transferred into competent cells and the supernatant was purified by NI column affinity chromatography and the purity is > 85% (by SDS-PAGE) .
Solubility
PBS, 4M Urea, PH7.4
Molecular Weight
~55kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Host or Source
E.coli
AA Sequence
CAGCCTAGTGTTAGCCCGGGTGAACCGAGCCCGCCGAGCATTCATCCGGGCAAAAGCGATCTGATTGTTCGTGTTGGTGATGAAATTCGTCTGCTGTGCACCGATCCGGGCTTCGTGAAATGGACCTTCGAAATTCTGGATGAAACCAATGAAAATAAGCAGAATGAATGGATTACCGAAAAAGCAGAAGCCACCAATACCGGCAAATATACCTGCACCAATAAACATGGTCTGAGTAATAGTATCTATGTGTTCGTTCGCGATCCGGCCAAACTGTTCCTGGTGGATCGTAGCCTGTATGGTAAAGAAGATAATGATACCCTGGTGCGCTGTCCGCTGACCGATCCGGAAGTTACCAATTATAGTCTGAAAGGTTGCCAGGGCAAACCGCTGCCGAAAGATCTGCGCTTCATTCCGGATCCGAAAGCAGGCATTATGATTAAAAGCGTTAAACGCGCATATCATCGTCTGTGTCTGCATTGCAGCGTGGATCAGGAAGGTAAAAGTGTTCTGAGCGAAAAATTCATTCTGAAAGTGCGCCCGGCATTCAAAGCAGTTCCGGTTGTGAGCGTGAGTAAAGCAAGTTATCTGCTGCGCGAAGGCGAAGAATTCACCGTGACCTGTACCATTAAAGATGTGAGTAGCAGCGTGTATAGTACCTGGAAACGTGAAAATAGTCAGACCAAACTGCAGGAAAAATATAATAGTTGGCATCATGGTGACTTCAATTATGAACGTCAGGCCACCCTGACCATTAGCAGCGCCCGCGTTAATGATAGCGGCGTGTTCATGTGTTATGCAAATAATACCTTCGGTAGCGCCAATGTGACCACCACCCTGGAAGTTGTGGATAAAGGCTTCATTAATATCTTCCCGATGATTAATACCACCGTGTTCGTGAATGATGGTGAAAATGTGGATCTGATTGTGGAATATGAAGCATTCCCGAAACCGGAACATCAGCAGTGGATCTATATGAATCGCACCTTCACCGATAAATGGGAAGATTATCCGAAAAGCGAAAATGAAAGCAATATTCGTTACGTGAGTGAACTGCATCTGACCCGCCTGAAAGGCACCGAAGGCGGCACCTATACCTTCCTGGTGAGTAATAGCGATGTGAATGCAGCAATTGCCTTCAATGTGTATGTGAATACCAAACCGGAAATTCTGACCTATGATCGCCTGGTGAATGGCATGCTGCAGTGCGTTGCAGCCGGCTTCCCGGAACCGACCATTGATTGGTACTTCTGCCCGGGTACCGAACAGCGTTGTAGCGCCAGTGTGCTGCCGGTGGATGTTCAGACCCTGAATAGCAGCGGCCCGCCGTTCGGTAAACTGGTTGTTCAGAGCAGTATTGATAGTAGTGCCTTCAAACATAATGGCACCGTGGAATGCAAAGCCTATAATGATGTGGGTAAAACCAGCGCATACTTCAACTTCGCCTTCAAAGGTAATAATAAAGAACAGATTCACCCGCATACCCTGTTCACCCCG

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