CD117 Antibody [ACK2]

• Background:

  The ACK2 monoclonal antibody specifically reacts with mouse CD117 (c-Kit receptor), a 145 kDa transmembrane tyrosine-kinase receptor encoded by the Kit gene. The c-Kit receptor, also known as stem cell factor receptor, is expressed on hematopoietic progenitor cells in adult bone marrow, in progenitors of erythroid and myeloid lineages, and precursors of B and T cells. CD117 enhances the proliferation and the differentiation of the hematopoietic progenitor cells and seems to enhance the development of T cells, as the c-Kit receptor and its ligand are expressed by the thymus.

• NCBI Gene ID:

  16590

• Swiss Prot:

  P05532

• Host:

  Rat

• Reactivity:

  Mouse

• Clonality:

  Monoclonal

• Clone:

  ACK2

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies, Functional Antibodies

• Field of Research:

  Cancer

• Purification:

  The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.

• Concentration:

  Batch dependent

• Buffer:

  Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  The product should be stored undiluted at 4˚ C and should be protected from prolonged exposure to light. Do not freeze.

• Fragment:

  Rat IgG2b, kappa

• Specificity:

  The ACK2 monoclonal antibody specifically reacts with mouse CD117 (c-Kit receptor), a 145 kDa transmembrane tyrosine-kinase receptor encoded by the Kit gene.

• Symbol:

  Kit

• NCBI Official Name:

  Kit oncogene

• NCBI Organism:

  Mus musculus

• Background Reference 01:

  Godfrey, D. I., Kennedy, J., Mombaerts, P., Tonegawa, S., Zlotnik, A. (1994) . Onset of TCR-beta gene rearrangement and role of TCR-beta expression during CD3-CD4-CD8-thymocyte differentiation. The Journal of Immunology,152 (10), 4783-4792.

• Background Reference 02:

  Godfrey, D. I., Zlotnik, A. L. B. E. R. T., Suda, T. A. K. A. S. H. I. (1992) . Phenotypic and functional characterization of c-kit expression during intrathymic T cell development.The Journal of Immunology,149 (7), 2281-2285.

• Background Reference 03:

  Feng, H., Sandlow, J. I., Sandra, A. (1998) . The c-kit receptor and its possible signaling transduction pathway in mouse spermatozoa.Molecular reproduction and development,49 (3), 317-326.

• Other Product Names:

  W, Bs, Fdc, Ssm, SCO1, SCO5, SOW3, CD117, c-KIT, Tr-kit, Gsfsco1, Gsfsco5, Gsfsow3, Kit

• Tested Applications:

  Flow, Functional Assays, IHC, ICC, WB

• Physical Properties:

  Liquid