LIMPII Recombinant Protein

• Background:

  Lysosome membrane protein II (LIMPII), also known as SCARB2, is a type III multi-pass membrane glycoprotein that is located primarily in limiting membranes of lysosomes and endosomes on all tissues and cell types so far examined. Earlier studies in mice and rat suggested that this protein may participate in membrane transportation and the reorganization of endosomal/lysosomal compartment. The protein deficiency in mice was reported to impair cell membrane transport processes and cause pelvic junction obstruction, deafness, and peripheral neuropathy. Further studies in human showed that this protein is identified as a receptor for EV71 (human enterovirus species A, Enterovirus 71) and CVA16 (coxsackievirus A16) which are most frequently associated with hand, foot and mouth disease (HFMD) . Mutations in this gene caused an autosomal recessive progressive myoclonic epilepsy-4 (EPM4), also known as action myoclonus-renal failure syndrome (AMRF) . Alternatively spliced transcript variants encoding different isoforms have been found for this gene. In addition, LIMPII also has been shown to bind thrombospondin-1, may contribute to the pro-adhesive changes of activated platelets during coagulation, and inflammation.

• NCBI Gene ID:

  12492

• Swiss Prot:

  O35114

• Accession Number:

  O35114

• Tag:

  C-6 His tag

• Type:

  Recombinant Proteins

• Source:

  Human Cells

• Buffer:

  Lyophilized from a 0.2 um filtered solution of 50mM Tris-Citrate, 0.3M NaCl, pH6.5. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in ddH2O.

• Shipping Conditions:

  Room Temp

• Calculated Molecular Weight:

  73.4 kD

• Applications Notes:

  This recombinant protein can be used for biological assays. For research use only.

• NCBI Official Name:

  Scavenger receptor class B, member 2

• NCBI Organism:

  Mus musculus

• Other Product Names:

  Lysosome membrane protein 2, 85 kDa lysosomal membrane sialoglycoprotein, LGP85, Lysosome membrane protein II, LIMP II, Scavenger receptor class B member 2, Scarb2, SR-B2, CD36L2

• Species:

  Mouse

• Physical Properties:

  Lyophilized

• CAS Number:

  9000-83-3