LEPR Recombinant Protein

• Background:

  Leptin receptor (LEPR) is also known as LEP-R, cluster of differentiation 295 (CD295), OB-R and B219, is a single-transmembrane-domain receptor of the gp130 family of cytokine receptors. Leptin receptor exists as homodimer and binds Leptin with high affinity, thus mediates the biological function of the adipocyte-specific hormone Leptin. LEPR is a receptor for leptin (an adipocyte-specific hormone that regulates body weight), and is involved in the regulation of fat metabolism, as well as in a novel hematopoietic pathway that is required for normal lymphopoiesis. Mutations in this protein have been associated with obesity and pituitary dysfunction. Interaction of leptin and leptin receptor is crucial for body weight and bone mass regulation in mammals through hypothalamic effects on satiety and energy expenditure. Meanwhile, research data supports a leptin receptor activation model based on ligand-induced conformational changes.

• NCBI Gene ID:

  3953

• Swiss Prot:

  P48357

• Accession Number:

  NP_002294.2

• Tag:

  C-Fc Tag

• Type:

  Recombinant Proteins

• Source:

  HEK293 cells

• Field of Research:

  Cancer, Neuroscience, Obesity, Signal Transduction

• Purity:

  >95% as determined by SDS-PAGE.

• Buffer:

  PBS, pH7.4

• Shipping Conditions:

  Room Temp

• Storage Conditions:

  Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.

• Calculated Molecular Weight:

  121 kDa

• Applications Notes:

  This recombinant protein can be used for WB. For research use only.

• NCBI Official Name:

  Leptin receptor

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Tutino V, et al., 2011, Anticancer Res., 31 (10) :3381-3.

• Background Reference 02:

  Xu YJ., et al., 2011, J Cancer Res Clin Oncol., 137 (12) :1841-8.

• Background Reference 03:

  Sharma K, et al., 2003, Am. J. Physiol. Renal Physiol. 284 (6) : F1138–44.

• Other Product Names:

  LEPR, CD295, DKFZp686B1731, OBR, Leptin receptor

• Tested Applications:

  WB

• Species:

  Human

• Physical Properties:

  Lyophilized

• CAS Number:

  9000-83-3