Plasma kallikrein Recombinant Protein

• Background:

  KLKB1 is a 638 amino acids protein that belongs to the peptidase S1 family and plasma kallikrein subfamily. It contains a peptidase S1 domain and four apple domains. The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin. It participates in the surface-dependent activation of blood coagulation, fibrinolysis, kinin generation and inflammation.Plasma prekallikrein deficiency causes a prolonged activated partial thromboplastin time in patients.

• NCBI Gene ID:

  3818

• Swiss Prot:

  P03952

• Accession Number:

  P03952

• Tag:

  C-6 His tag

• Type:

  Recombinant Proteins

• Source:

  Human Cells

• Field of Research:

  Cancer, Cell Cycle, Signal Transduction

• Buffer:

  Supplied as a 0.2 um filtered solution of 20mM TrisHCl,150mM NaCl,10% Glycerol, pH8.0. It is not recommended to reconstitute to a concentration less than 100 ug/ml.

• Shipping Conditions:

  Dry Ice

• Calculated Molecular Weight:

  70.2 kD

• Applications Notes:

  This recombinant protein can be used for biological assays. For research use only.

• NCBI Official Name:

  Kallikrein B1

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  Plasma kallikrein, Fletcher factor, Kininogenin, Plasma prekallikrein, KLKB1, KLK3, KLKB1

• Species:

  Human

• Physical Properties:

  Liquid

• CAS Number:

  9000-83-3