Kallikrein 7 Recombinant Protein

• Background:

  Human Kallikrein 7 is a member of the tissue kallikrein family of extracellular serine proteases that is made up of 15 members. It is predominantly expressed in the skin. A major physiological function of Kallikrein 7 is to regulate the desquamation process (the shedding of corneocytes from the outer layer of the epidermis) through proteolysis of the intercellular adhesive structures between corneocytes. Dysregulation of Kallikrein 7 has been linked to several inflammatory skin diseases including atopic dermatitis, psoriasis, and Netherton syndrome. Studies have shown that Kallikrein 5 is a potential physiological activator for Kallikrein 7. The proform of Kallikrein 7 can be activated by thermolysin.

• NCBI Gene ID:

  5650

• Swiss Prot:

  P49862

• Accession Number:

  P49862

• Tag:

  C-6 His tag

• Type:

  Recombinant Proteins

• Source:

  Human Cells

• Field of Research:

  Cancer, Cell Cycle, Signal Transduction

• Buffer:

  Supplied as a 0.2 um filtered solution of 20mM HEPES, 150mM NaCl, pH 7.5. It is not recommended to reconstitute to a concentration less than 100 ug/ml.

• Shipping Conditions:

  Dry Ice

• Calculated Molecular Weight:

  26.17 kD

• Applications Notes:

  This recombinant protein can be used for biological assays. For research use only.

• NCBI Official Name:

  Kallikrein related peptidase 7

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  Kallikrein-7, hK7, Serine Protease 6, Stratum Corneum Chymotryptic Enzyme, hSCCE, KLK7, PRSS6, SCCE, SCEE

• Species:

  Human

• Physical Properties:

  Liquid

• CAS Number:

  9000-83-3