IzTRAIL, Soluble Recombinant Protein

• Background:

  IzTRAIL is a newly available, highly active recombinant form of soluble human TRAIL. Due to a trimerizing N-terminal isoleucine zipper (iz) motif the intrinsic trimerization of TRAIL, required for apoptosis-inducing activity of TRAIL, is enhanced when compared to non-tagged soluble human TRAIL (shTRAIL) . Therefore, izTRAIL is a potent inducer of apoptosis in many human cancer cells, but not normal human hepatocytes. In addition, the half-life of izTRAIL is about eight-fold higher than the half-life of shTRAIL. These properties render izTRAIL highly suitable for both, in vitro and in vivo use, particularly for studies in which investigators plan to transfer their in vitro results into an in vivo system with human cancer cells in xenotransplant settings examining susceptibility to TRAIL-induced apoptosis.

• NCBI Gene ID:

  8743

• Swiss Prot:

  Q02223

• Accession Number:

  P50591

• Tag:

  Isoleucine zipper motif Tag

• Type:

  Recombinant Proteins

• Source:

  E. coli

• Field of Research:

  Apoptosis, Cancer, Growth Factors, Immunology

• Concentration:

  0.1mg/ml after reconstitution.

• Buffer:

  Contains 20mM TRIS-Cl, 0.5M arginine-HCl, 100mM NaCl, 0.02% Tween 20. Reconstitute with 100 μ l sterile water.

• Shipping Conditions:

  Room Temp

• Storage Conditions:

  Stable for at least 6 months after receipt when stored at -20˚ C.

• Applications Notes:

  This recombinant proteins is for research use only.

• NCBI Official Name:

  Tumor necrosis factor (ligand) superfamily, member 10

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  Apo-2L, TNFSF10, CD253

• Species:

  Human

• Protein ID:

  4507593

• Physical Properties:

  Lyophilized

• CAS Number:

  9000-83-3