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IL-33 Recombinant Protein

CAT: 0223-95-111Size: 0.05 mgDry Ice: YesHazardous: No
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CAT#:0223-95-111Size:0.05 mg
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Background
Interleukin-33 (IL-33) is a recently identified member of the IL-1 family of cytokines whose other members include IL-1, IL-1Ra and IL-18 (1,2) . Its receptor has been shown to be ST2, an IL-1 receptor family member that also acts as a negative regulator of TLR-IL-1R signaling (1,3) and IL-1R accessory protein (IL-1RAcP) (4) . Receptor binding of IL-33 activates NF-B and MAP kinases and induces the expression of TH2-associated cytokines such as IL-4, IL-5 and IL-6. Prolonged IL-33 treatment of mice led to the development of eosinophilia, splenomegaly, and severe pathological changes in mucosal organs such as lungs, esophagus and small intestine (2) . Recent experiments have shown that IL-33 can also co-localize with heterochromatin and possesses transcriptional repressor activities, indicating that IL-33 may function as both a proinflammatory cytokine and an intracellular nuclear factor with transcriptional regulatory properties (5) . This recombinant protein represents the cleaved and presumably activated form of IL-33, but has not been tested in any biological assays.
CAS Number
9000-83-3
NCBI Gene ID
90865
Swiss Prot
O95760
Accession Number
NP_254274
Tag
Fusion Partner:
Type
Recombinant Proteins
Source
E. coli
Field of Research
Chemokines & Cytokines, Immunology, Innate Immunity
Purity
~95%
Buffer
100mM sodium phosphate, 500mM NaCl, 25 mM imidazole, 10% gycerol
Shipping Conditions
Dry Ice
Storage Conditions
Store in working aliquots at -70˚ C. Avoid freeze/thaw cycles. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
Calculated Molecular Weight
22 kDa (Calculated)
Applications Notes
This recombinant protein can be used for WB and ELISA. For research use only.
NCBI Official Name
Interleukin 33
NCBI Organism
Homo sapiens
Background Reference 01
Schmitz J, Owyang A, Oldham E, et al. IL-33, and interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines. Immunity 2005; 23:479-90.
Background Reference 02
Dinarello CA. Interleukin-18, a proinflammatory cytokine. Eur. Cytokine Netw. 2000; 11:483-6.
Background Reference 03
Brint EK, Xu D, Liu H, et al. ST2 is an inhibitor of interleukin 1 receptor and Toll-like receptor 4 signaling and maintains endotoxin tolerance. Nat. Immunol. 2004; 5:373-9.
Background Reference 04
Chackerian AA, Oldham ER, Murphy EE, et al. IL-1 receptor accessory protein and ST2 comprise the IL-33 receptor complex. J. Immunol. 2007; 179:2551-5.
Other Product Names
IL-33 Antibody: DVS27, IL1F11, NF-HEV, NFEHEV, C9orf26, NFHEV, Interleukin-33, Interleukin-1 family member 11, IL-33
Tested Applications
ELISA, WB
Species
Human
Protein ID
15559209
Physical Properties
Liquid

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