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IL-33 Antibody

CAT: 0223-36-250Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0223-36-250Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Interleukin-33 (IL-33; HF-NEV; IL-1F11), a member of the IL-1 family of cytokines, is expressed by many cell types following pro-inflammatory stimulation and is thought to be released on cell lysis. The 30kDa human IL33 is converted by CASP1 to a 18kDa protein. IL33 binds to and signals through ST2 (IL1R1) and its stimulation recruits MYD88, IRAK, IRAK4, and TRAF6, followed by phosphorylation of ERK1 (MAPK3) /ERK2 (MAPK1), p38 (MAPK14), and JNK. The ability of IL-33 to target numerous immune cell types, like Th2-like cells, mast cells, and B1 cells, and to induce cytokine and chemokine production underlines its potential in influencing the outcome of a wide range of diseases, such as arthritis, asthma, atopic allergy & anaphylaxis, cardiovascular disease/atherosclerosis, nervous system diseases, and sepsis.
NCBI Gene ID
77125
Swiss Prot
Q8BVZ5
Accession Number
68565902
Host
Rabbit
Reactivity
Mouse
Immunogen
Recombinant mouse IL-33.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Innate Immunity
Concentration
1 mg/ml
Buffer
Liquid. 0.2um-filtered solution in PBS, pH 7.4. Contains no preservatives.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Stable for at least 6 months after receipt when stored at -20˚ C.
Specificity
Recognizes mouse IL-33. Detects a band of ~18kDa by Western blot. Does not cross-react with human IL-33.
Applications Notes
ELISA: (direct and indirect: 1:2,000-1:5,000) . Western Blot: (1:2,000-1:5,000 using ECL; suggested blocking and dilution buffer is PBST containing 0.05% Tween 20 and 5% skim milk; suggested incubation time is 1 hour at room temperature) . Optimal conditions must be determined individually for each application.
Symbol
Il33
NCBI Official Name
Interleukin 33
NCBI Organism
Mus musculus
Other Product Names
Interleukin-33; IL-1F11; NF-HEV
Tested Applications
ELISA, WB
Protein ID
Q8BVZ5
Physical Properties
Liquid

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